Journal Home > Volume 1 , Issue 1
Health Care Science 2022, 1(1): 11-13 https://doi.org/10.1002/hcs2.7
Editorial | Open Access | Issue | Published: 13 July 2022

Porcine cytomegalovirus in xenotransplantation: The new frontier in human transplantation?

Show Author's Information Björn Nashan1 ( )
Department of Organ Transplantation Center, First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China
Keywords:
porcine, cytomegalovirus, frontier, xenotransplantation
Cite this article:
Nashan B. Porcine cytomegalovirus in xenotransplantation: The new frontier in human transplantation?. Health Care Science, 2022, 1(1): 11-13. https://doi.org/10.1002/hcs2.7
Download citation
EndNote(RIS)
BibTeX

302

Views

6

Downloads

Citations

2

Crossref

N/A

WoS

0

Scopus

N/A

CSCD

Full text About this article

menu
Full text
Outline
About this article

Porcine cytomegalovirus in xenotransplantation: The new frontier in human transplantation?

Show Author's information Björn Nashan1 ( )
Department of Organ Transplantation Center, First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China
Keywords: porcine, cytomegalovirus, frontier, xenotransplantation

References(25)

Accessed 8 May (2022). https://www.technologyreview.com//05/04/1051725/xenotransplant-patient-died-received-heart-infected-with-pig-virus/
DOI
Griffith BP, Goerlich CE, Singh AK et al. Genetically modified porcine‐to‐human cardiac xenotransplantation. 2022, NEJM.org. https://doi.org/10.1056/NEJMoa2201422
DOI Google Scholar
Cooper DK, Keogh AM, Brink J, Corris PA, Klepetko W, Pierson RN, et al. Report of the xenotransplantation advisory committee of the international society for heart and lung transplantation: the present status of xenotransplantation and its potential role in the treatment of end‐stage cardiac and pulmonary diseases. J Heart Lung Transplant. 2000;19:1125–65.
DOI Google Scholar
Mohiuddin MM, Singh AK, Corcoran PC, Thomas Iii ML, Clark T, Lewis BG, et al. Chimeric 2C10R4 anti‐CD40 antibody therapy is critical for long‐term survival of GTKO.hCD46.hTBM pig‐to‐primate cardiac xenograft. Nat Commun. 2016;7:11138.
DOI Google Scholar
Denner J, Tönjes RR. Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses. Clin Microbiol Rev. 2012;25(2):318–43.
DOI Google Scholar
Denner J. Porcine endogenous retroviruses and xenotransplantation, 2021. Viruses. 2021;13:2156.
DOI Google Scholar
Godehardt AW, Fischer N, Rauch P, Gulich B, Boller K, Church GM, et al. Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15. Xenotransplantation. 2020;27(2):e12563.
DOI Google Scholar
Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, et al. Role of intrinsic (graft) versus extrinsic (host) factors in the growth of transplanted organs following allogeneic and xenogeneic transplantation. Am J Transplant. 2017;17:1778‐90.
DOI Google Scholar
Längin M, Mayr T, Reichart B, Michel S, Buchholz S, Guethoff S, et al. Consistent success in life‐sup‐porting porcine cardiac xenotransplantation. Nature. 2018;564:430‐3.
DOI Google Scholar
Denner J. Xenotransplantation and porcine cytomegalovirus. Xenotransplantation. 2015;22(5):329–35.
DOI Google Scholar
Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW. Diseases of swine. 10th ed.Ames, IA: Wiley‐Blackwell; 2012.
Whitteker JL, Dudani AK, Tackaberry ES. Human fibroblasts are permissive for porcine cytomegalovirus in vitro. Transplantation. 2008;86:155–62.
DOI Google Scholar
Fiebig, HA, Ivanusic D, Plotzki E, Hengel H, Neipel F, et al. Antibody cross‐reactivity between porcine cytomegalovirus (PCMV) and human herpesvirus‐6 (HHV‐6). Viruses2017, 9, 317.
DOI Google Scholar
Gu W, Zeng N., Zhou L, Ge X., Guo X, Yang H. Genomic organization and molecular characterization of porcine cytomegalovirus. Virology. 2014;460–461:165–72.
DOI Google Scholar
Mueller NJ, Sulling K, Gollackner B, Yamamoto S, Knosalla C, Wilkinson RA, et al. Reduced efficacy of ganciclovir against porcine and baboon cytomegalovirus in pig‐to‐baboon xenotransplantation. Am J Transplant. 2003;3:1057–64.
DOI Google Scholar
Mueller NJ, Fishman JA. Herpesvirus infections in xenotransplantation: pathogenesis and approaches. Xenotransplantation. 2004;11:486–90.
DOI Google Scholar
Denner, Längin M, Reichart B, Krüger L, Fiebig U, Mokelke M, et al. Impact of porcine cytomegalovirus on long‑term orthotopic cardiac xenotransplant survival. Nature. 2020;10:17531.
DOI Google Scholar
Killoran K, Leedom Larson KR. Porcine cytomegalovirus Swine Health Information Center and Center for Food Security and Public Health. 2016. https://www.cfsph.iastate.edu/pdf/shic-factsheet-porcine-cytomegalovirus
Denner J. Xenotransplantation and hepatitis E virus. Xenotransplantation. 2015;22(3):167–73.
DOI Google Scholar
Mrzljak A, Novak R, Pandak N, Tabain I, Franusic L, Barbic L, et al. Emerging and neglected zoonoses in transplant population. World J Transplant. 2020;10(3):47‐63.
DOI Google Scholar
Hansrivijit P, Trongtorsak A, Puthenpura MM, Boonpheng B, Thongprayoon C, Wijarnpreecha K, et al. Hepatitis E in solid organ transplant recipients: a systematic review and meta‐analysis. World J Gastroenterol. 2021;27(12):1240‐54.
DOI Google Scholar
Villar E, Boissonnat P, Sebbag L, Hendawy A, Cahen R, Trolliet P, et al. Poor prognosis of heart transplant patients with end‐stage renal failure. Nephrol Dial Transplant. 2007;22:1383–89.
DOI Google Scholar
Clippinger AJ, Maguire TG, Alwine JC. The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol. 2011;85:3930‐9.
DOI Google Scholar
Nashan B, Gaston R, Emery V, Säemann MD, Mueller NJ, Couzi L, et al. Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor‐based immunosuppressive therapy in de novo renal transplant recipients. Transplantation. 2012;93:1075–85.
DOI Google Scholar
Sommerer C, Suwelack B, Dragun D., Schenker P, Hauser IA, Witzke O, et al. An open‐label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients. Kidney Int. 2019;96:231–44.
DOI Google Scholar
Publication history
Copyright
Acknowledgements
Rights and permissions

Publication history

Published: 13 July 2022
Issue date: August 2022

Copyright

© 2022 The Authors.

Acknowledgements

None declared.

Rights and permissions

Return