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Background

West Bengal is experiencing an unanticipated risk of eclampsia among pregnant women and it persists as the leading cause of maternal mortality. This study aimed to investigate the predictors for maternal deaths due to eclampsia in West Bengal.

Methods

The study adopted retrospective mixed methods covering facility and community‐based maternal death review approaches. Facility‐based data were used for 317 deceased cases wherein the community‐based review approach was used in 40 cases. An in‐depth interview was also performed among 12 caregivers.

Results

One‐third of maternal deaths occurred due to eclampsia, and this accounted for the leading cause of maternal deaths in West Bengal. A younger age, a primigravida or nulliparous status, absence of antenatal care (ANC), and residence in rural areas appeared to have the highest risk of developing eclampsia. The majority of pregnant women had an irregular antenatal check‐up history, particularly during the second trimester of pregnancy. The rate of eclampsia‐related maternal death was higher in women residing more than 49 km from the studied hospitals. Most of the deceased women were referred to three or more hospitals before their death. Gravidity, the number of ANC visits, the mode of delivery, and delays at different levels were significant confounders of death due to eclampsia. The risk of death due to eclampsia was two times higher among women without ANC and those who had a cesarean section than that in their counterparts.

Conclusions

Women in West Bengal have a high risk of preeclampsia and eclampsia resulting in maternal mortality and morbidity. Gravidity, the number of ANC visits, the mode of delivery, and delays in recognition of eclampsia contribute to the risk of maternal deaths. The establishment of separate eclampsia units, enhanced screening, and preventive and treatment procedures may optimize managing eclampsia.


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Socioeconomic and epidemiological milieu of maternal death due to eclampsia in West Bengal, India: A mixed methods study

Show Author's information Md Illias Kanchan Sk ( )
International Institute for Population Sciences, Mumbai, India

Abstract

Background

West Bengal is experiencing an unanticipated risk of eclampsia among pregnant women and it persists as the leading cause of maternal mortality. This study aimed to investigate the predictors for maternal deaths due to eclampsia in West Bengal.

Methods

The study adopted retrospective mixed methods covering facility and community‐based maternal death review approaches. Facility‐based data were used for 317 deceased cases wherein the community‐based review approach was used in 40 cases. An in‐depth interview was also performed among 12 caregivers.

Results

One‐third of maternal deaths occurred due to eclampsia, and this accounted for the leading cause of maternal deaths in West Bengal. A younger age, a primigravida or nulliparous status, absence of antenatal care (ANC), and residence in rural areas appeared to have the highest risk of developing eclampsia. The majority of pregnant women had an irregular antenatal check‐up history, particularly during the second trimester of pregnancy. The rate of eclampsia‐related maternal death was higher in women residing more than 49 km from the studied hospitals. Most of the deceased women were referred to three or more hospitals before their death. Gravidity, the number of ANC visits, the mode of delivery, and delays at different levels were significant confounders of death due to eclampsia. The risk of death due to eclampsia was two times higher among women without ANC and those who had a cesarean section than that in their counterparts.

Conclusions

Women in West Bengal have a high risk of preeclampsia and eclampsia resulting in maternal mortality and morbidity. Gravidity, the number of ANC visits, the mode of delivery, and delays in recognition of eclampsia contribute to the risk of maternal deaths. The establishment of separate eclampsia units, enhanced screening, and preventive and treatment procedures may optimize managing eclampsia.

Keywords: India, eclampsia, maternal mortality, determinants, West Bengal

References(34)

1

Von Dadelszen P, Bhutta ZA, Sharma S, Bone J, Singer J, Wong H, et al. The community‐level interventions for pre‐eclampsia (CLIP) cluster randomised trials in Mozambique, Pakistan, and India: an individual participant‐level meta‐analysis. Lancet. 2020;396(10250):553–63. https://doi.org/10.1016/S0140-6736(20)31128-4

2

Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk factors of pre‐eclampsia/eclampsia and its adverse outcomes in low‐and middle‐income countries: a WHO secondary analysis. PLoS One. 2014;9(3):e91198. https://doi.org/10.1371/journal.pone.0091198

3

Hug L, Alexander M, You D, Alkema L. National, regional, and global levels and trends in neonatal mortality between 1990 and 2017, with scenario‐based projections to 2030: a systematic analysis. Lancet Global Health. 2019;7(6):e710–20. https://doi.org/10.1016/S2214-109X(19)30163-9

4

Lozano R, Wang H, Foreman KJ, Rajaratnam JK, Naghavi M, Marcus JR, et al. Progress towards millennium development goals 4 and 5 on maternal and child mortality: an updated systematic analysis. Lancet. 2011;378(9797):1139–65. https://doi.org/10.1016/S0140-6736(11)61337-8

5

Malik A, Jee B, Gupta SK. Preeclampsia: disease biology and burden, its management strategies with reference to India. Pregnancy Hyper. 2019;15:23–31. https://doi.org/10.1016/j.preghy.2018.10.011

6

Nobis PN, Hajong A. Eclampsia in India through the decades. J Obstetrics Gynecol India. 2016;66(1):172–6. https://doi.org/10.1007/s13224-015-0807-5

7

Ahmed KY, Rwabilimbo AG, Abrha S, Page A, Arora A, Tadese F, et al. Factors associated with underweight, overweight, and obesity in reproductive age Tanzanian women. PLoS One. 2020;15(8):e0237720. https://doi.org/10.1371/journal.pone.0237720

8

Lisowska M, Pietrucha T, Sakowicz A. Preeclampsia and related cardiovascular risk: common genetic background. Curr Hypertens Rep. 2018;20(8):71. https://doi.org/10.1007/s11906-018-0869-8

9

Meyur R, Sadhu A, Mondal H, Khanra SK. A light microscopic study of placentae in eclamptic mothers at term. J Res Med Sci. 2017;5(9):4082–6. https://doi.org/10.18203/2320-6012.ijrms20173987

10

Magee LA, Sharma S, Nathan HL, Adetoro OO, Bellad MB, Goudar S, et al. The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: a prospective population‐level analysis. PLoS Med. 2019;16(4):e1002783. https://doi.org/10.1371/journal.pmed.1002783

11

Agrawal S, Walia GK, Staines‐Urias E, Casas JP, Millett C. Prevalence of and risk factors for eclampsia in pregnant women in India. Family Med Community Health. 2017;5(4):225–44. https://doi.org/10.15212/FMCH.2016.0121

12

Das R, Biswas S. Eclapmsia: the major cause of maternal mortality in eastern India. Ethiop J Health Sci. 2015;25(2):111–6. https://doi.org/10.4314/ejhs.v25i2.2

13

Bhattacharyya SK, Majhi AK, Seal SL, Mukhopadhyay S, Kamilya G, Mukherji J. Maternal mortality in India: a 20‐year study from a large referral medical college hospital, West Bengal. J Obstetrics Gynaecol Res. 2008;34(4):499–503. https://doi.org/10.1111/j.1447-0756.2008.00721.x

14

Sk MIK, Paswan B, Anand A, Chowdhury P, Naskar TK. Deaths during pregnancy, childbirth and puerperium: exploring causes, context and evidence from Eastern India. J Obstetrics Gynaecol Res. 2020;46:2366–74. https://doi.org/10.1111/jog.14466

15

Jana N, Barik S, Arora N. Re: clinical practice patterns on the use of magnesium sulphate for treatment of pre‐eclampsia and eclampsia: a multi‐country survey: Magnesium sulphate regimens for eclampsia: should we adopt same'goldstandard'for all women. BJOG: Int J Obstetrics Gynaecol. 2018;125(7):909. https://doi.org/10.1111/1471-0528.15149

16

Ronsmans C, Campbell O. Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy. BMC Public Health. 2011;11(S3):S8. https://doi.org/10.1186/1471-2458-11-S3-S8

17
NIPCCD. An analysis of levels and trends in maternal health and maternal mortality ratio in India. 2015. National Institute of Public Cooperation and Child Development.
18
WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Trends in maternal mortality: 1990 to 2015: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. 2016. World Health Organization; 2015. http://apps.who.int/iris/bitstream/handle/10665/194254/9789241565141_eng.pdf;jsessionid=6E186501EC864EC6A3019A72554201BA
19

Goldenberg RL, McClure EM, MacGuire ER, Kamath BD, Jobe AH. Lessons for low‐income regions following the reduction in hypertension‐related maternal mortality in high‐income countries. Int J Gynaecol Obstetrics. 2011;113(2):91–5. https://doi.org/10.1016/j.ijgo.2011.01.002

20

Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, et al. The International Federation of gynecology and obstetrics (FIGO) initiative on pre‐eclampsia: a pragmatic guide for first‐trimester screening and prevention. Intl J Gynaecol Obstetrics. 2019;145(suppl 1):1–33. https://doi.org/10.1002/ijgo.12802

21

Chaemsaithong P, Poon LC, Sahota DS. First trimester preeclampsia screening and prediction. Am J Obstet Gynecol. 2022;226:S1071–97. https://doi.org/10.1016/j.ajog.2020.07.020

22

Aukes AM, Arion K, Bone JN, Li J, Vidler M, Bellad MB, et al. Causes and circumstances of maternal death: a secondary analysis of the community‐level interventions for pre‐eclampsia (CLIP) trials cohort. Lancet Global Health. 2021;9(9):e1242–51. https://doi.org/10.1016/S2214-109X(21)00263-1

23

Keskinkılıç B, Engin Üstün Y, Sanisoğlu S, Şahin Uygur D, Keskin HL, Karaahmetoğlu S, et al. Maternal mortality due to hypertensive disorders in pregnancy, childbirth, and the puerperium between 2012 and 2015 in Turkey: a nation‐based study. J Turkish‐German Gynecol Assoc. 2017;18(1):20–5. https://doi.org/10.4274/jtgga.2016.0244

24

Abejirinde IOO, Douwes R, Bardají A, Abugnaba‐Abanga R, Zweekhorst M, van Roosmalen J, et al. Pregnant women's experiences with an integrated diagnostic and decision support device for antenatal care in Ghana. BMC Pregnancy Childbirth. 2018;18(1):209. https://doi.org/10.1186/s12884-018-1853-7

25

Yaliwal RG, Jaju PB, Vanishree M. Eclampsia and perinatal outcome: a retrospective study in a teaching hospital. J of Clin and Diagn Res. 2011;5(5):1056–9. https://doi.org/10.7860/JCDR/2011/.1527

26

Worke MD, Enyew HD, Dagnew MM. Magnitude of maternal near misses and the role of delays in Ethiopia: a hospital based cross‐sectional study. BMC Res Notes. 2019;12(1):585. https://doi.org/10.1186/s13104-019-4628-y

27

Braunthal S, Brateanu A. Hypertension in pregnancy: pathophysiology and treatment. SAGE Open Med. 2019;7:1–15. https://doi.org/10.1177/2050312119843700

28

Mohta M, Duggal S, Chilkoti GT. Randomised double‐blind comparison of bolus phenylephrine or ephedrine for treatment of hypotension in women with pre‐eclampsia undergoing caesarean section. Anaesthesia. 2018;73(7):839–46. https://doi.org/10.1111/anae.14268

29

Amorim MM, Souza ASR, Katz L. Planned caesarean section versus planned vaginal birth for severe pre‐eclampsia. Cochrane Database Syst Rev. 2017;10:1–18. https://doi.org/10.1002/14651858.CD009430.pub2

30

Mazda Y, Tanaka M, Terui K, Nagashima S, Inoue R. Postoperative renal function in parturients with severe preeclampsia who underwent cesarean delivery: a retrospective observational study. J Anesth. 2018;32(3):447–51. https://doi.org/10.1007/s00540-018-2492-x

31

Sarkar S. Prevalence and determinants of the use of caesarean section (CS) in the dichotomy of ‘public’ and ‘private’ health facilities in West Bengal. India. Clin Epidemiol Global Health. 2020;8:1377–83. https://doi.org/10.1016/j.cegh.2020.05.017

32
IIPS. National Family Health Survey (NFHS‐4) 2015‐16. International Institute for Population Sciences (IIPS). 2017.
33

Skjærven R, Wilcox AJ, Lie RT. The interval between pregnancies and the risk of preeclampsia. N Engl J Med. 2002;346(1):33–8. https://doi.org/10.1056/NEJMoa011379

34

Graham NM, Gimovsky AC, Roman A, Berghella V. Blood loss at cesarean delivery in women on magnesium sulfate for preeclampsia. J Maternal‐fetal Neonatal Med. 2016;29(11):1817–21. https://doi.org/10.3109/14767058.2015.1064107

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Publication history

Received: 08 October 2022
Accepted: 04 November 2022
Published: 21 December 2022
Issue date: February 2023

Copyright

© 2022 The Authors. Health Care Science published by John Wiley & Sons Ltd on behalf of Tsinghua University Press.

Acknowledgements

ACKNOWLEDGMENTS

I would like to thank the Principals and Registrars of Kolkata and Malda Medical Colleges and Hospitals for providing maternal death‐related data. I am grateful to Prof. Balram Paswan and Prof. T. K. Naskar for their continuous insight and guidance during my research. I am also thankful to Mr. Sandeep Chatterjee, Mr. Samiun Mondal, and Dr. Ismile Sheikh, the assistant superintendent of the respective medical college and hospitals, for their help in completinge this study. The author received no financial support for the research, authorship, and/or publication of this article.

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This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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