Special Issue Editors

Guest Editor

Prof. Chi-Tang Ho

Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA

E-mail: ctho@aesop.rutgers.edu

Co-editors

Prof. Shiming Li

College of Agricultural & Biological Sciences, Huanggang Normal University, Huanggang, China; Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA

E-mail: shiming@rutgers.edu

Prof. Wensheng Zhang

Engineering Research Center of Natural Medicine, Beijing Normal University, China

E-mail: zws@bnu.edu.cn

Description

With the field of aging biology research expanding at an unprecedented rate, the exploration of anti-ageing strategies has emerged as a highly topical and novel area of study over the past few decades. These strategies include oxidative stress control, epigenetic reprogramming, circadian rhythm regulation, gut microbiota adjustment, and pharmaceutical intervention. However, one of the chief driving forces for ageing, carbonyl stress, has been relatively understudied. This stress is responsible for multiple pathological metabolic conditions, including diabetic complications, cardiovascular diseases, depression, dementia, cancer, and ageing. Therefore, combating carbonyl stress is urgent in postponing ageing and extending a healthy lifespan. Foods, with their potential to reduce carbonyl stress and elongate longevity, are a promising avenue of research. This special issue, dedicated to the anti-ageing effects and mechanisms of food bioactives in combating carbonyl stress, aims to gather contributions and research that could significantly advance our understanding of ageing and its related metabolic conditions.

The scope of this special issue will cover ageing-related, but not limited to:

• Scavenging reactive carbonyl species (RCS), e.g., methylglyoxal (MG), by bioactives from a food matrix;
• Inhibition of the formation of advanced glycation end products (AGEs);
• Down-regulation of the receptor of AGEs (RAGE);
• Blockading the AGE/RAGE pathway;
• Inhibiting RAGE expression-related inflammation such as AGE/RAGE/NF-κB pathway;
• Disease prevention via reducing the levels of MG/AGEs/RAGE;
• Functional foods and diabetic complications related to carbonyl stress;
• Food control of carbonyl stress related to cardiovascular diseases;
• Other ageing-related control of carbonyl stress by foods and or food matrices

Keywords

Ageing, carbonyl stress, reactive carbonyl species (RCS), methylglyoxal (MG), food bioactives, functional foods, diabetes complication, cardiovascular diseases

Submission Deadline: March 31, 2025

Publication Date: August 31, 2025