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Review | Open Access

Current Advances in Preclinical Patient-Derived Cultivation Models for Individualized Drug Response Prediction in Pancreatic Cancer

Benjamin Heckelmann, Jannis Duhn, Rüdiger Braun

Published: 22 April 2026

2026, 34(5): 1

Review | Open Access

The Role of Immunotherapy in Resectable Non-Small Cell Lung Cancer

Francesco Petrella, Andrea Cara, Enrico Mario Cassina, [...], Lidia Libretti, Emanuele Pirondini, Federico Raveglia, Maria Chiara Sibilia, Antonio Tuoro << Fewer

Published: 22 April 2026

2026, 34(5): 2

Review | Open Access

Primary Debulking Surgery Versus Neoadjuvant Chemotherapy in Advanced Ovarian Cancer: A Meta-Analysis of All Randomized Clinical Trials with Subgroup Analysis by Patient Profile

Carlo Ronsini, Giuseppe Cucinella, Maria Cristina Solazzo, [...], Mariano Catello Di Donna, Cono Scaffa, Stefano Cianci, Manuela Ludovisi, Sandro Pignata, Vito Chiantera << Fewer

Published: 22 April 2026

2026, 34(5): 3

Review | Open Access

AI-Guided Discovery of Oncogenic Signaling Crosstalk in Tumor Progression and Drug Resistance

Edward Sutanto, Rinni Sutanto, Sara Velichkovikj, [...], Nikola Hadzi-Petrushev, Mitko Mladenov, Dimiter Avtanski, Radoslav Stojchevski << Fewer

Published: 22 April 2026

2026, 34(5): 4

Review | Open Access

Cancer-Associated Arterial Thrombosis: Mechanisms and Risk Factors

Kassiani Lalechou, Despoina Pantazi

Published: 22 April 2026

2026, 34(5): 5

Review | Open Access

Melatonin in Integrative Oncology: Biological Mechanisms, Therapeutic Evidence and Implementation Strategies

Jarosław Nuszkiewicz, Joanna Wróblewska, Marek Jóźwiak, Marta Pawłowska

Published: 22 April 2026

2026, 34(5): 6

Review | Open Access

Therapeutic Targets for Overcoming BCR::ABL1 Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia

Masanobu Tsubaki, Taira Matsuo, Rie Komori

Published: 22 April 2026

2026, 34(5): 7

Review | Open Access

Extrachromosomal DNA in Solid Tumors—Landscape, Immune Effects, and Resistance to Targeted Therapy

Omar Badran, Siraj Attarya

Published: 22 April 2026

2026, 34(5): 8

Review | Open Access

Navigating the Labyrinth of Hepatocellular Carcinoma: Leveraging AI/ML for Precision Oncology

Abdul Manan, Sidra Ilyas

Published: 22 April 2026

2026, 34(5): 9

Review | Open Access

In Vivo CAR-T Therapy for Cancer Treatment: Mechanisms, Technological Advances, and Clinical Translation

Lu Hao, Jiao Lu, Jisu Xue

Published: 22 April 2026

2026, 34(5): 10

Review | Open Access

Multidimensional Regulatory Network of YAP1 Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review

Jun-Hui Chen, Si-Run Du, Chang Liu, [...], Bei-Bei Liu, Hai-Ying Xu, Xin-Ying Ji, Bo Feng, Chun-Zheng Ma, Jun-Hui Guo << Fewer

Published: 22 April 2026

2026, 34(5): 11

Review | Open Access

Navigating the Tumor Microenvironment in Colorectal Liver Metastasis: Barriers to Therapy and Emerging Opportunities

Pengtao Hu, Junjie Sun, Jian Lu, [...], Chunlei Ge, Hanzhi Sun, Chengyu Lv << Fewer

Published: 22 April 2026

2026, 34(5): 12

Article | Open Access

Bevacizumab and Paclitaxel in Advanced, Hormone Receptor-Positive Breast Cancer: Multifactor Dimensionality Reduction Methodology to Identify Best Overall Survival

Luigi Coltelli, Paola Orlandi, Chiara Finale, [...], Gianna Musettini, Luna Chiara Masini, Marco Scalese, Giulia Soria, Elena Sartori, Ylenia Nodari, Giada Arrighi, Arianna Bandini, Marta Banchi, Costanza Tacchi, Donghao Tang, Barbara Salvadori, Lucia Tanganelli, Simona Giovannelli, Mirco Pistelli, Samanta Cupini, Maurizio Lucchesi, Alessandro Cosimi, Giulia Lorenzini, Elisa Biasco, Chiara Caparello, Giulia Acconci, Eloise Fontana, Eleonora Bona, Azzurra Farnesi, Antonio Pellino, Andrea Marini, Ermelinda De Maio, Irene Stasi, Cecilia Barbara, Enrico Sammarco, Javier Rosada, Giacomo Allegrini, Guido Bocci << Fewer

Published: 22 April 2026

2026, 34(5): 13

Article | Open Access

Data Mining for Identification of Targets and Repurposed Drugs to Eliminate Persistent Chronic Myeloid Leukaemia Stem Cells: Targeting RAS/RAF Signalling

I Made Bayu Anggriawan, Heather G. Jørgensen

Published: 22 April 2026

2026, 34(5): 14

Article | Open Access

Comparative Analysis of Tumor Microbiota Identifies a Metastatic-Specific Bacterial Signature, Highlighting Streptococcus spp. As the Predominant Hub across Cancers

Nevena Todorovic, Sara Bertorello, Giulia Nannini, [...], Serena Pillozzi, Simonetta Bianchi, Maria Raffaella Ambrosio, Elena Niccolai, Simone Baldi, Amedeo Amedei << Fewer

Published: 22 April 2026

2026, 34(5): 15

Article | Open Access

Glutathione Peroxidases 1 and 3 Immunoscores in Clear Cell Renal Cell Carcinoma: New Insights from a Case-Series Study

Dimitra P. Vageli, Panagiotis G. Doukas, Nikolaos Papageorgiou, [...], Chrysanthi A. Markou, Konstantina Zacharouli, Maria Ioannou << Fewer

Published: 22 April 2026

2026, 34(5): 16

Article | Open Access

Elevated C-Reactive Protein as a Potential Biomarker for Neurological Adverse Events in Immune Checkpoint Inhibitor Therapy: A Prospective Cohort Study

Laura Duzzi, Nora Möhn, Emily Narten, [...], Janin Thomas, Susann Mahjoub, Lea Grote-Levi, Konstantin Jendretzky, Sandra Nay, Felix Konen, Jonas Wiegmann, Gernot Beutel, Tabea Fröhlich, Benjamin-Alexander Bollmann, Thomas Wirth, Imke von Wasielewski, Florian H. Heidel, Ralf Gutzmer, Thomas Skripuletz, Philipp Ivanyi << Fewer

Published: 22 April 2026

2026, 34(5): 17

Article | Open Access

Integrated Global Phosphoproteomic, Bioinformatic, and Machine Learning Analysis Reveals Regulatory Networks of TOP1, TOP2A, TOP2B, and C1orf35 in Hepatocellular Carcinoma (HCC)

Aktham Mestareehi

Published: 22 April 2026

2026, 34(5): 18

Article | Open Access

The Real-World Endocrine Toxicity Profile of ICIs, VEGFR-TKIs, and Their Combination: Analysis of the FDA Adverse Event Reporting System (FAERS) Database

Nicola Marrano, Mariangela Caporusso, Cosimo Matino, [...], Irene Caruso, Carlo Ganini, Mimma Rizzo, Ludovico Di Gioia, Angelo Cignarelli, Sebastio Perrini, Luigi Laviola, Camillo Porta, Francesco Giorgino, Annalisa Natalicchio << Fewer

Published: 22 April 2026

2026, 34(5): 19

Article | Open Access

CDKN1A/p21 Influences the Survival and Expansion of Breast Cancer Stem Cells after Oxidative Damage

Evangelos Manousakis, Cristina Moreta-Moraleda, Clàudia Martinez Miralles, [...], Anna Tomàs Pujolà, Houda Baccara, Laia Liñán Franquet, Montserrat Montañés Albó, Roberto Ferrari, Roni H. G. Wright << Fewer

Published: 22 April 2026

2026, 34(5): 20

Article | Open Access

Mebendazole Attenuates Cellular Invasion in a 3D Culture Model of Meningioma by Disrupting Rho-GTPase-Mediated Microtubule Function

Munro Matthew James, López Vásquez Clara Elena, Wickremesekera Agadha, [...], Chan Alex Ho Chuen, Gray Clint Lee << Fewer

Published: 22 April 2026

2026, 34(5): 21

Article | Open Access

Upregulation of Sox2 Following Saracatinib Treatment Contributes to a Resistant Phenotype in Colorectal Cancer Cells under Growth Factor-Supplemented Conditions

Chanwoong Yoon, Euihyeon Na, Min Joo Choi, Sang-Pil Yoon

Published: 22 April 2026

2026, 34(5): 23

Article | Open Access

Machine Learning (ML) and Molecular Dynamics–Driven Optimization of VEGFR2 Ligands against Hepatocellular Carcinoma

Farzana Yasmeen, Abdul Manan, Wook Kim, Sangdun Choi

Published: 22 April 2026

2026, 34(5): 24

Article | Open Access

Plexin A2 Knockdown Enhances Apoptosis in Chemotherapy Treated Melanoma Cells

Nadezhda Palkina, Aleksandra Esimbekova, Ekaterina Lapkina, [...], Victoriia Kutsenko, Ivan Zinchenko, Egor Dereviankin, Elena Anisimova, Andrei Savchenko, Tatiana Ruksha << Fewer

Published: 22 April 2026

2026, 34(5): 28

Article | Open Access

Targeting Oncogenic lncRNA KRT7-AS to Induce Ferroptosis Suppresses Ovarian Cancer Progression

Yan Zhu, Bin Guan, Wencai Guan, [...], Jihong Zhang, Shiyu Wang, Jimin Shi, Wei Fan, Qi Lu, Lingyun Zhang, Guoxiong Xu << Fewer

Published: 22 April 2026

2026, 34(5): 29

Article | Open Access

Identify MTDH as a Key Gene of Radio-Resistance in Colorectal Cancer Based on Multi-Omics and Experimental Validation

Wei Xu, Yuanyuan Zhang, Yizhi Ge, Yesong Guo

Published: 22 April 2026

2026, 34(5): 30

Article | Open Access

Regulation of Histone Emulsification by HPDL via LDHA/LDHB Promotes EC Cell Proliferation

Yan Wang, Jialei Zhu, Shiyang Wei, [...], Lijie Jin, Zhanqiu Liu, Jie Xu, Nana Yang, Xuefeng Jiang, Caizhi Wang, Lingling Wang << Fewer

Published: 22 April 2026

2026, 34(5): 31

Article | Open Access

CDCA7 Promotes Proliferation and Suppresses Apoptosis in Gastric Cancer via HELLS-Mediated Chromatin Remodeling

Jun Jiang, Yi-Ran Li, Xiaoting Wang, [...], Jian Li, Fangzhou Ye, Jiayi Wang, Huanqing Li, Li Feng << Fewer

Published: 22 April 2026

2026, 34(5): 32

Article | Open Access

Circ72688 Drives Breast Cancer Invasion and Metastasis via the miR-654-5p/ORAI2 Axis

Haojie Yang, Zicong Tan, Zihao Liu, [...], Kang Chen, Ning Liufu, Fengtao Ji << Fewer

Published: 22 April 2026

2026, 34(5): 33

Article | Open Access

SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma

Chunhui Tian, Weipin Xie, Wen Li, [...], Huaiyu Gu, Xuebao Liu, Busheng Tong, Yehai Liu, Huaiyuan Zong << Fewer

Published: 22 April 2026

2026, 34(5): 34

Article | Open Access

Elucidating the Potential Targets and Mechanisms of Bisphenol A-Induced Prostate Cancer Based on Network Toxicology and Molecular Docking Analyses

Ashuai Du, Dianbin Guo, Dongbo Yuan, [...], Kai Li, Yuanyuan Luo, Songsong Tan, Xuchao Dai, Bo Yu, Wanxiang You, Junjie Zhao, Bo Yan, Kehua Jiang, Xiaofei Fan, Jianguo Zhu << Fewer

Published: 22 April 2026

2026, 34(5): 35

Article | Open Access

Isoliquiritigenin Impedes Breast Cancer Progression through PITX1–PFKP-Mediated Glycolysis Reprogramming

Cong Liu, Zhenyu Zhang, Ronghua Feng, [...], Mengsi Zeng, Hui Li, Mei Zhu, Lan Zhuang, Zongjuan Li, Tao Wu << Fewer

Published: 22 April 2026

2026, 34(5): 36

Case Report | Open Access

Case Report: A Case of Neuroendocrine Carcinoma of the Endometrium with Deficient DNA Mismatch Repair Had Achieved Clinical Complete Response after Combination Therapy

Xie Ding, Xinfeng Liu, Cheng Dai, [...], Xiaoxiao Wang, Zhaopeng Zheng << Fewer

Published: 22 April 2026

2026, 34(5): 37