Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 13 Issue 5
Volume 13 Issue 5, September 2026
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RAPID COMMUNICATION
Rapid Communication | Open Access
Depletion of Kif13b promotes neuroinflammatory attack against myelin in an experimental autoimmune encephalomyelitis mouse model
Jingxuan Chen, Yitong Xu, Guolin Miao, [...], Liwen Zheng, Kaikai Lu, Wenxi Zhang, Wei Huang, Yuhui Wang, Xunde Xian << Fewer
Published: 19 November 2025
2026, 13(5)
Rapid Communication | Open Access
The oncogenic role of CCDC178 in intrahepatic cholangiocarcinoma through LGR4-dependent signaling and immune modulation
Yunlu Jia, Yanli Wang, Yongxia Chen, [...], Dayong Zheng, Wenguang Fu, Xiaochen Zhang, Yunkun Lu, Jian Ruan << Fewer
Published: 28 October 2025
2026, 13(5)
Rapid Communication | Open Access
Variants in ARHGAP21, encoding a Rho GTPase-activating protein, are associated with focal epilepsy and neurodevelopmental disorders
Zilong Ye, Bingmei Li, Longshan Xie, [...], Lingxia Fei, Xinguo Lu, Yunhua He, Jie Wang, Yongjun Chen, Weiping Liao, Yiwu Shi << Fewer
Published: 15 December 2025
2026, 13(5)
Rapid Communication | Open Access
Integrative pan-cancer analysis identifies CCHCR1 as a prognostic biomarker and therapeutic target driving EMT in hepatocellular carcinoma via PI3K/AKT activation
Shuting Huang, Wanqiu Li, Kaifang Wang, [...], Yu Cai, Lirui Qian, Yiran Liu, Feng Gao, Tong Fang, Kin Yip Tam, Ou Sha << Fewer
Published: 28 November 2025
2026, 13(5)
Rapid Communication | Open Access
Identification of novel compound heterozygous variants of the PNPLA6 gene in Oliver-McFarlane syndrome with concomitant insulin resistance
Ruojun Qiu, Mingming Tang, Weifen Zhu, [...], Binghong Wang, Wenyu Li, Yongzhen Lei, Fenping Zheng << Fewer
Published: 14 December 2025
2026, 13(5)
Rapid Communication | Open Access
An autophagy-related molecule reticulon 3 functions as a novel prognostic biomarker in hepatocellular carcinoma
Zhu Xie, Wei Wang, Peng Yu, [...], Mingdong Zhang, Zixin Hu, Hongyan Wang << Fewer
Published: 08 November 2025
2026, 13(5)
Rapid Communication | Open Access
NLRP3 deficiency reprograms hepatic glucose metabolism but fails to ameliorate hepatic inflammation and fibrosis in the MCD model
Yong Zou, Xiaowen Wu, Jingyi Wang, [...], Jie Xia, Sen Zhang, Shuzhe Ding, Weina Liu, Zhengtang Qi << Fewer
Published: 06 November 2025
2026, 13(5)
Rapid Communication | Open Access
Integrative analysis reveals the clinical utility of cancer-associated fibroblast-derived signature, and its implication for young-onset thyroid cancer
Shenglong Xu, Tianyao Chu, Hongyan Chen, [...], Jing Wang, Yufei Wang, Yaoyao Liang, Xinlei Zhang, Yan Zhao, Peng Zhang << Fewer
Published: 17 October 2025
2026, 13(5)
Rapid Communication | Open Access
SERTAD4-AS1 suppresses pancreatic cancer progression by stabilizing SERTAD4 and inhibiting the Notch1 pathway
Yuchen Tang, Jie Wang, Jun Yao, [...], Haoran Li, Bin Yi, Chengqing Yu, Yijun Wei, Jian Yang, Zixiang Zhang, Jian Zhou << Fewer
Published: 23 September 2025
2026, 13(5)
Rapid Communication | Open Access
Loss of minichromosome maintenance 4 leads to early renal dysplasia and cystogenesis outcomes
Jing Huang, Hui-Ling Xiang, Qian Yuan, [...], Chun Zhang, Xian-Fang Meng << Fewer
Published: 08 December 2025
2026, 13(5)
Rapid Communication | Open Access
Decoding age-stratified mutational landscapes in CNS lymphoma via genomic and survival profiling for precision oncology
Jiawen Chen, Hongwei Liu, Qisheng Tang, [...], Huihui Chai, Peng Wang, Ruize Zhu, Tong Chen, Tianwen Li, Zhifeng Shi << Fewer
Published: 17 November 2025
2026, 13(5)
Rapid Communication | Open Access
miR-27a expression during inflammatory organ injury associated with ARDS and a novel tissue-specific knockout model
Jieun Kim, Synthea Horton, Oleg D. Makarevich, [...], Yan Levitsky, Thu Thien Tran, In Hyuk Bang, Xiangsheng Huang, Xuebo Chen, Katherine Figarella, Xiaoyi Yuan << Fewer
Published: 06 December 2025
2026, 13(5)
Rapid Communication | Open Access
GBM-Dx SIGNAL: Blood transcriptomics complementing neuroimaging to differentiate glioblastoma recurrence from treatment effects
Dan Qi, James Murchison, Ekokobe Fonkem, [...], Jason H. Huang, Erxi Wu << Fewer
Published: 06 January 2026
2026, 13(5)
Rapid Communication | Open Access
Two novel murine esophageal cancer cell line models exhibiting distinct sensitivities to immunotherapy
Jinling Zhang, Yichen Yao, Jiajia Hu, [...], Chenyi Wu, Jiaying Chen, Yanxing Chen, Zixin Qin, Qi Zhao, Runjie Huang, Feng Wang, Yingnan Wang << Fewer
Published: 30 January 2026
2026, 13(5)
Rapid Communication | Open Access
Human Gordon Holmes Syndrome modeling in mice reveals essential function of RNF216 ubiquitination in spermatogenesis and male fertility
Jeffrey M. Mann, Chao Wei, Xiaoyuan Yan, [...], Huirong Xie, Elena Y. Demireva, Chen Chen << Fewer
Published: 29 January 2026
2026, 13(5)
Rapid Communication | Open Access
Single-cell transcriptomics reveals EpCAM regulates the development and morphology of intestinal epithelium via controlling the EGFR pathway
Zili Lei, Ya Nie, Lulu Liu, [...], Yanhong Yang, Xuan Liu, Guibin Chen, Yunjuan Wang, Wanwan Liu, Qing Hu, Ting Lin, Jiao Guo << Fewer
Published: 09 February 2026
2026, 13(5)
Rapid Communication | Open Access
Multi-omics Mendelian randomization combined with single-cell and spatial transcriptomics: Multidimensional validation of drug targets for osteoarthritis
Bo Yang, Feng Li, Jindong Cao, [...], Yuxuan Xie, Yifeng Da, Xuejun Yang, Xiaodong Zhao, Wenhua Xing, Jing Tian << Fewer
Published: 23 September 2025
2026, 13(5)
Rapid Communication | Open Access
Ammonia-induced cell death patterns in glioblastoma: Immune landscape, prognostic signature, and therapeutic target identification
Sheng-Qi Hu, Jing Wang, Jing Wang, [...], Chun Zeng, Rudong Chen << Fewer
Published: 12 December 2025
2026, 13(5)
REVIEW ARTICLE
Review Article | Open Access
From inactivation to intervention: X chromosome silencing in disease pathogenesis and emerging therapeutic strategies
Yuan Fu, Xuling Tan, Lixia Qin, Chunyu Wang
Published: 05 December 2025
2026, 13(5)
Review Article | Open Access
Current progress and role of lncRNAs in HBV infection and progression of hepatocellular carcinoma
Faisal Mahmood, Maher Un Nisa Awan, Meng-Ting Luo, [...], Xiao Li, Xiao-bin Peng, Jun Xu, Jia Wei, Tai-Cheng Zhou << Fewer
Published: 13 October 2025
2026, 13(5)
Review Article | Open Access
Trained immunity: New insights into pathogenesis and therapeutic targets in diabetes and diabetic complications
Qiming Gong, Yuqing Huang, Fahui Liu, [...], Tingting Zhou, Wei Huang, Yong Xu << Fewer
Published: 19 November 2025
2026, 13(5)
Review Article | Open Access
Pan-cancer analysis and mechanistic insights of tuft cell-like tumors
Mengling Ye, Yuyang Liu, Hui Li
Published: 14 November 2025
2026, 13(5)
Review Article | Open Access
Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies
Xiangyun Yan, Weijian Zeng, Peitao Ma, [...], Junpeng Yao, Tingting Ma, Ying Li << Fewer
Published: 07 November 2025
2026, 13(5)
Review Article | Open Access
Pathophysiological mechanisms of organ injury in Fabry disease: Update via multi-omics
Zhiyuan Wei, Junlan Yang, Zhongyu Han, [...], Xiaoliang Zhang, Bin Wang << Fewer
Published: 25 November 2025
2026, 13(5)
Review Article | Open Access
The multifaceted landscape of T cell exhaustion in organ transplantation: From molecular mechanisms (epigenetics, transcription, metabolism) to induction strategies
Yining Wang, You Wu, Yufei Shen, [...], Yujia Chen, Yifan Zhao, Xiandong Zeng, Kang He << Fewer
Published: 06 December 2025
2026, 13(5)
Review Article | Open Access
Ferroptosis and prostate cancer: A translational path from molecular mechanisms to precision therapy
Yixiang Huang, Yuanxin Ma, Jiachen He, Tanjing Song
Published: 08 December 2025
2026, 13(5)
Review Article | Open Access
Interaction between N6-methyladenosine (m6A) modification and toxicant-related neurodegeneration: From neural development to pathophysiology
Zhou She, Peng Huang, Senlin Luo, [...], Lu Zhang, Hong Peng, Yufen Tang, Yuqiong Chen, Jinwen Luo, Wangxin Duan, Lingjuan Liu, Liqun Liu << Fewer
Published: 17 December 2025
2026, 13(5)
Review Article | Open Access
CXorf67 in malignancies: Deciphering epigenetic landscapes and clinical implications for precision oncology
Xinning Yu, Huatao Wu, Yangzheng Lan, [...], Wenjia Chen, Jing Liu << Fewer
Published: 10 November 2025
2026, 13(5)
Review Article | Open Access
Obesity accelerates aging: Mechanisms and therapeutic implications
Rui Zhang, Linlin Liu, Xiaoman Shi, Yanming Ren
Published: 11 December 2025
2026, 13(5)
Review Article | Open Access
Autophagy as a therapeutic target for cisplatin-resistant gastric cancer
Luling Wei, Yingfei Zhou, Jiashuo Li, [...], Hongzhao Qi, Shasha Wang << Fewer
Published: 19 December 2025
2026, 13(5)
Review Article | Open Access
Research progress on the mechanisms and animal models of Ménière’s disease
Siyuan Liu, Yanshi Li, Yuting Zhang, [...], Yuxiao Zheng, Chen Jin, Lin Chen, Guohua Hu, Wenqi Zuo << Fewer
Published: 02 January 2026
2026, 13(5)
Review Article | Open Access
Purinergic signaling in osteoarthritis: Mechanistic insights into pathogenesis and therapeutic targeting
Hongliang Li, Tianqi Wang, Zi Wang, [...], Jincen Hou, Zhong Li, Jiyuan Yan << Fewer
Published: 23 December 2025
2026, 13(5)
Review Article | Open Access
Unraveling the role of PIWI/piRNAs in stem cell therapy: Epigenetic mechanisms and therapeutic potentials
Ying Yang, Xiangping Luo, Ermao Li, [...], Zhengmao Li, Feiyan Zou, Jiayang Liao, Yizhi Wu, Bo Wei << Fewer
Published: 18 September 2025
2026, 13(5)
FULL LENGTH ARTICLE
Full Length Article | Open Access
Artesunate directly targets glucosylceramidase to suppress hepatocellular carcinoma proliferation and trigger apoptosis
Xia Mao, Xiangying Yan, Yawen Chen, [...], Bingbing Cai, Wenjia Chen, Ya Lin, Na Lin, Yanqiong Zhang << Fewer
Published: 20 January 2026
2026, 13(5)
Full Length Article | Open Access
Hypoxia-induced m6A demethylation promotes hepatocellular carcinoma progression by preventing the degradation of Gal-1 mRNA
Xianzhi Gao, Bian Shu, Diguang Wen, [...], Jiao Lu, Hua Song, Ziyi Sheng, Yu You, Zuojin Liu << Fewer
Published: 18 September 2025
2026, 13(5)
Full Length Article | Open Access
IRP1/ARID3A complex promotes pancreatic cancer chemoresistance by suppressing CYGB-related ferroptosis
Zeru Li, Cheng Qin, Bangbo Zhao, [...], Tianyu Li, Yutong Zhao, Lirui Huang, Haoyu Shi, Yiping Xie, Yutong Yan, Xiangyu Zhang, Weibin Wang << Fewer
Published: 24 September 2025
2026, 13(5)
Full Length Article | Open Access
ADAR1p110 promotes hepatocellular carcinoma metastasis via the miR-451a/TUBA1A axis
Liangzhan Sun, Hui Yang, Pengchao Hu, [...], Jingyi Zheng, Yuyang Du, Shasha Wu, Han Gao, Hao Luo, Yanchen Wang, Fenfen Wang, Jingsong Yan, Xin-Yuan Guan, Yan Li << Fewer
Published: 12 July 2025
2026, 13(5)
Full Length Article | Open Access
Uncovering genes driving developmental stage progression in prostate cancer through spatial transcriptomics
Yongjun Quan, Mingdong Wang, Fan Zou, [...], Hong Zhang, Yishan Zhang, Yongchen Jin, Hao Ping << Fewer
Published: 11 December 2025
2026, 13(5)
Full Length Article | Open Access
Activation of the Jak2/Stat3 pathway by ROS-dependent signaling cascades initiates hepatitis B virus-induced hepatic inflammatory responses
Rui Song, Shasha Yu, Xueyan Chen, [...], Ning Ling, Dachuan Cai, Hong Ren, Min Chen << Fewer
Published: 23 September 2025
2026, 13(5)
Full Length Article | Open Access
CXCR4 reduces aldosterone synthesis via regulating CYP11B2 expression
Jiang Chen, Shumin Yang, Xinyue Yang, [...], Jiayu Li, Yifan He, Chuan Peng, Wei Zhang, Yi Yang, Junlong Li, Hongji Li, Furong He, Yong Xu, Wei Huang, Jinbo Hu, Qifu Li, Linqiang Ma << Fewer
Published: 28 November 2025
2026, 13(5)
Full Length Article | Open Access
CUDC-907 inhibits glioblastoma and enhances glioblastoma sensitivity to temozolomide by inhibiting DNA damage repair
Chencheng Fang, Pan Gou, Dandan Zhang, [...], Xuanxuan Wu, Xiao Li, Man Li, Lu Gan, Jinjin Luo, Hongjuan Cui, Man Xu, Ping Liang << Fewer
Published: 24 November 2025
2026, 13(5)
Full Length Article | Open Access
Transcription cofactor Hes6 interacts with Twist1 to facilitate EMT and promote gastric carcinogenesis by activating the PI3K/AKT signaling
Can Fang, Zhiwei Peng, Yaru Sang, [...], Zihao Ren, Kang Wang, Nuo Xu, Ying Li, Tingting Guo, Yinan Zhu, Shangxue Yan, Kongwang Hu << Fewer
Published: 05 May 2025
2026, 13(5)
Full Length Article | Open Access
SIRT5 mediates the pro-osteogenic effects of estrogen through FDX1 demalonylation and cuproptosis inhibition in mesenchymal stem cells
Fanglin Ye, Dongmei He, Wenting Liu, [...], Jie Cai, Aihua Ye, Zhenghao Xu, Wenge He, Yuxi Su, Junyi Liao, Baicheng He << Fewer
Published: 17 March 2026
2026, 13(5)
Full Length Article | Open Access
Agrimoniin ameliorates intrapulmonary angiogenesis and improves hypoxemia in hepatopulmonary syndrome via PGC-1α activation and glycolysis down-regulation
Ziyang Zeng, Zhiyong Yang, Yuhao Lei, [...], Meiyu Zhou, Lin Chen, Yang Chen, Xianfeng Wu, Huiling Cao, Chunyong Yang, Xiaobo Wang, Karine Belguise, Yujie Li, Bin Yi << Fewer
Published: 18 November 2025
2026, 13(5)
Full Length Article | Open Access
A parallel-risk framework accurately predicts hematopoietic stem cell transplantation outcomes and identifies benefiting patients in pediatric AML
Yance Feng, Yali Shen, Ke Huang, [...], Qian Li, Yu Tao, Rongqiu Liu, Liping Zhan, Hua Yang, Yang Xun, Yichao Xu, Wenli Tang, Binjun Xiong, Hui Shi, Liting Cheng, Li Wei, Hua You << Fewer
Published: 23 December 2025
2026, 13(5)
Full Length Article | Open Access
8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism
Jing Liu, Yongle Zhao, Xue Gong, [...], Lin Yuan, Shengyong Yang, Wenwen Jian, Han Yan, Honglin Chen, Zhicheng Yang, Yiheng Sun, Tianle Gu, He Lu, Hongyun Zhao, Zeng Tu << Fewer
Published: 26 September 2025
2026, 13(5)
Full Length Article | Open Access
Lipid droplet-associated gene signatures classify metabolic subtypes and identify PLIN3 as a key driver in hepatocellular carcinoma
Huiying Gu, Qiumin Wu, Haibei Zhao, [...], JingLong Du, Zhenzhen Zhang, Juan Chen << Fewer
Published: 03 February 2026
2026, 13(5)
Full Length Article | Open Access
Type Ⅲ interferons attenuates Th1/Th17 cell pathogenicity and regulates retinal pigment epithelium cells via NLRP1/NLRP3 signaling axis in autoimmune uveitis
Wujiao Wang, Qingfeng Wang, Jinyu Cai, [...], Guannan Su, Wanyun Zhang, Shuai Su, Yunfan Zheng, Chaokui Wang, Peizeng Yang << Fewer
Published: 27 November 2025
2026, 13(5)
Full Length Article | Open Access
The therapeutic effect of nicotinamide riboside chloride on ameliorating alcohol-induced neuronal damage with a focus on mitochondrial unfolded protein response and mitophagy
Jinyang Wang, Jianan Wang, Wei Xie, [...], Qi Shen, Chengbin Wang, Ruibing Li, Shixiong Deng << Fewer
Published: 18 October 2025
2026, 13(5)
Full Length Article | Open Access
Potential oncogenic role of occult hepatitis B virus pre-S mutations: Activation of Akt/mTOR/Cyclin D1 signaling drives cell cycle dysregulation and proliferation in hepatocellular carcinogenesis
Huizhen Sun, Ling Mei, Shi Song, [...], Qian Su, Ying Yan, Huimin Ji, Jie Ma, Le Chang, Lunan Wang << Fewer
Published: 06 November 2025
2026, 13(5)
Full Length Article | Open Access
Rejuvenation of corticospinal neurons enhances rehabilitation-associated corticospinal tract axon sprouting and functional recovery post photothrombotic ischemic stroke in mice
Bin Sun, Li Sun, Lixiang Zhang, [...], Xinyu Xue, Qiuyan Tian, Lei Wu, Mei Li, Jian Huang, Hong Ni, Lixiao Xu, Chenxi Feng, Jing Ren, Hongliang Huo, Xia Zhang, Xing Feng, Wenhao Zhou, Wanliang Guo, Yaobo Liu, Rong Ju, Zhenlang Lin, Xiaofeng Yang, Xin Ding << Fewer
Published: 22 December 2025
2026, 13(5)
Full Length Article | Open Access
Identification of the homozygous truncating mutation in CNTD1 as a novel genetic cause of diminished ovarian reserve
Liwei Sun, Yi Chen, Keya Tong, [...], Weiwei Liu, Bei Liu, Yifan Wang, Guoning Huang, Jingyu Li << Fewer
Published: 24 October 2025
2026, 13(5)