Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 13 Issue 4
Volume 13 Issue 4, July 2026
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RESEARCH HIGHLIGHT
Research Highlight | Open Access
Translating multimodal foundation models into oncology: Toward a future where AI directs diagnosis and therapy
Kyung Chan Park, Wonbeak Yoo
Published: 27 November 2025
2026, 13(4)
LETTER
Letter | Open Access
Renal adverse events in EGFR-TKI treatment: Comprehensive characterization of clinical patterns and molecular underpinnings
Huili Xiao, Anqi Lin, Wentao Xu, [...], Junyi Shen, Cuiying Chen, Jian Zhang, Ting Wei, Peng Luo << Fewer
Published: 28 November 2025
2026, 13(4)
RAPID COMMUNICATION
Rapid Communication | Open Access
MAFA-expressing panniculus carnosus regulates skin twitching in mice
Junqi Jia, Xinyue Mei, Yixiu Liu, [...], Yang Yan, Guang Yu, Lan Zhou, Changming Wang << Fewer
Published: 11 December 2025
2026, 13(4)
Rapid Communication | Open Access
SP1 lactylation promotes endometrial cancer cell stemness via regulation of CENPL expression
Jian Ma, Ziyu Zhang, Bo Wang, [...], Wantong Wang, Fanfei Kong, Xiao-Xin Ma << Fewer
Published: 05 December 2025
2026, 13(4)
Rapid Communication | Open Access
Immune patterns of the tumor microenvironment in PD-L1+ EGFR+ HNSCC patients received anti-PD-1 and EGFR-based neoadjuvant therapy
Yuan Zhi, Wenhao Ren, Shaoming Li, [...], Jingjing Zheng, Jianzhong Song, Ling Gao, Keqian Zhi << Fewer
Published: 24 October 2025
2026, 13(4)
Rapid Communication | Open Access
Ribonucleotide reductase M1 regulates the cell cycle via minichromosome maintenance proteins
Agnes Malysa, Jenny M. Kreahling, Scott N. Freeman, [...], Bin Bao, Jiawei Zhao, Xiaohong Zhang, Manohar Ratnam, Gerold Bepler << Fewer
Published: 08 November 2025
2026, 13(4)
Rapid Communication | Open Access
Optimizing anti-seizure medication selection for epilepsy in EAST/SeSAME syndrome: Insights from DrugBank and STRING databases
Lin-Yan Hu, Lin Wan, Fang Han, [...], Yang Huang, Gang Zhu, Wen-Qi Cao, Wen He, Xiu-Yu Shi, Guang Yang, Li-Ping Zou << Fewer
Published: 09 September 2025
2026, 13(4)
Rapid Communication | Open Access
Identification of respiratory chain complex Ⅰ deficiency due to NDUFA5 variants as a novel cause of infantile fatal disease
Yang Wang, Xi Yang, Xue Yan, [...], Yumin Zhu, Xue Xia, Ting Li, Yi Liao, Bingkun Lei, Jingmin Yang, Deyuan Li << Fewer
Published: 06 November 2025
2026, 13(4)
Rapid Communication | Open Access
Single-cell RNA sequencing and large-panel NGS analysis reveal transcriptional heterogeneity and genomic characteristics of double primary lung cancer and thyroid cancer
Erteng Jia, Lixia Zhang, Yong Ge, [...], Li Li, He Zhang, Hao Zhang << Fewer
Published: 22 October 2025
2026, 13(4)
Rapid Communication | Open Access
RAB24 maps comprehensive clinical landscapes and mediates tumor malignant progression under the epigenetic regulation of miR-30b-3p and MMP11 in clear cell renal cell carcinoma
Fangshi Xu, Qiao Du, Gang Li, [...], Lingyu Guo, Jiancang Ma, Zhenlong Wang << Fewer
Published: 24 September 2025
2026, 13(4)
Rapid Communication | Open Access
Pathogenic variants in GBX2 cause craniofacial microsomia
Run Yang, Wenqing Han, Liang Wang, [...], Xin Chen, Ying Chen, Bowen Li, Maoxiang Qian, Dong Liu, Tianyu Zhang, Jing Ma << Fewer
Published: 21 August 2025
2026, 13(4)
Rapid Communication | Open Access
UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer
Min Zheng, Xisha Chen, Wenqiang Gan, [...], Lei Hou, Zhongmei Zhou, Ceshi Chen, Zhenzhen Liu, Yan Cheng << Fewer
Published: 24 November 2025
2026, 13(4)
Rapid Communication | Open Access
Arctigenin derivative (ARC-18) improved mitochondrial dysfunction and ameliorated frataxin deficiency symptoms via PGC-1α signaling
Qichao Gong, Xiao Han, Tiansu Liu, [...], Bocheng Xiong, Bingge Zhang, Yongmei Xie, Huali Wan, Tahir Ali, Xifei Yang, Shupeng Li << Fewer
Published: 01 September 2025
2026, 13(4)
Rapid Communication | Open Access
Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response
Tanya Singh, Kubra Trabzonlu, Aleksandra Spasova, [...], Phil Stephens, David E.J. Linden, Marianne B.M. van den Bree, Michael J. Owen, Jeremy Hall, Ujjwal Neogi, Adrian J. Harwood, Yasir Ahmed Syed << Fewer
Published: 06 November 2025
2026, 13(4)
Rapid Communication | Open Access
SF3B1K700E-driven transcriptional alterations in hematopoietic progenitors underlie blood cancer pathophysiology
Mengzhu Xue, Jianhong An, Erqiang Hu, [...], Wenjun Deng, Shanye Yin << Fewer
Published: 15 July 2025
2026, 13(4)
Rapid Communication | Open Access
APE1 inhibition-promoted pyroptosis triggers T-cell infiltration and enhances anti-tumor immunity in NSCLC
Fan Yang, Kaili Long, Yannan Qi, [...], Yuwei Dai, Feiyan Pan, Lingfeng He, Lindong Yang, Zhigang Guo, Zhigang Hu << Fewer
Published: 14 August 2025
2026, 13(4)
Rapid Communication | Open Access
Circulating tumor DNA predicts tumor recurrence in early-stage breast cancer: A meta-analysis
Luke F. Moat, John G. Mayer, David S. Puthoff, [...], Adam M. Bissonnette, Abdul R. Shour, Scott J. Hebbring, Adedayo A. Onitilo, Zhi Wen << Fewer
Published: 30 October 2025
2026, 13(4)
Rapid Communication | Open Access
Aminopyridine treatment for an adult patient of developmental and epileptic encephalopathy with a gain-of-function mutation in KCNA2
Lehong Gao, Yu Jia, Yingxue Yang, [...], Jia Chen, Liankun Ren << Fewer
Published: 07 August 2025
2026, 13(4)
Rapid Communication | Open Access
Identification of a novel prognostic gene signature associated with therapeutic resistance in hepatocellular carcinoma
Siliang Wang, Shuangshuang Wang, Xu Wang, [...], Yuxiang Sun, Xiao Du, Dan Han, Huanyu Ni, Yun Zhu, Huilian Shi, Zhaocong Yang << Fewer
Published: 30 August 2025
2026, 13(4)
Rapid Communication | Open Access
Juvenile idiopathic arthritis-associated RIG-I S144F variant inhibits type Ⅰ interferon signaling by blocking TRIM25-media ted ubiquitination
Li Zhang, Song Zhang, Yaoyao Shangguan, [...], Wanming Huang, Haolan Jin, Lili Li, Yuyin Qi, Yuxia Zhang, Ping Zeng, Huifang Xian << Fewer
Published: 07 August 2025
2026, 13(4)
Rapid Communication | Open Access
Multi-omics Mendelian randomization to identify novel immune therapeutic targets in benign prostatic hyperplasia
Zhenpeng Zhu, Xing Ji, Wenyuan Leng, [...], Weimin Hu, Chunru Xu, Xiaoyu Li, Jinqin Qian, Cuijian Zhang, Jian Lin << Fewer
Published: 19 November 2025
2026, 13(4)
Rapid Communication | Open Access
Comprehensive pan-cancer analysis reveals prognostic significance of CENPM and its role in immune infiltration
Jinyuan Tang, Sihang Zhang, Yongshuai Jiang, Mingming Zhang
Published: 16 August 2025
2026, 13(4)
Rapid Communication | Open Access
Machine learning-driven discovery of celastrol as an anti-inflammatory therapy suppressing NETs in severe influenza
Rui Gui, Lei Xue, Lele Li, [...], Jianmei Xiao, Li Peng, Meng Ni, Wanling Peng, Haoliang Wang, Zhili Liu, Guohong Deng << Fewer
Published: 09 December 2025
2026, 13(4)
Rapid Communication | Open Access
The single-cell landscape exploring abnormal T cell states and developmental trajectories in heterogeneous non-Hodgkin lymphoma
Yuqing Wang, Cong Wang, Dezhi Huang, [...], Chanmin Xiao, Qiqi Zhao, Miao Yu, Zheng Wang, Xi Zhang << Fewer
Published: 19 August 2025
2026, 13(4)
Rapid Communication | Open Access
Novel mechanisms and transcription factors associated with the therapeutic effect of Jakyakgamcho-tang on neuropathic pain
Su-Jin Baek, Musun Park, A Yeong Lee, [...], Jin-Mu Yi, Sang-Min Park, Seongwon Cha, No Soo Kim << Fewer
Published: 12 August 2025
2026, 13(4)
Rapid Communication | Open Access
Up-regulated IL-36 expression promotes a pro-tumorigenic phenotype in pancreatic ductal adenocarcinoma
Jianhong An, Quanxing Liao, Ziqin Yu, [...], Zihao Du, Juan Du, Qiang Xiao, Tingting Jiang, Changwen Huang, Keping Xie << Fewer
Published: 09 December 2025
2026, 13(4)
Rapid Communication | Open Access
RFX3 loss disrupts non-coding RNA networks in iPSC-derived pancreatic progenitors
Noura Aldous, Aldana Alnesf, Ahmed K. Elsayed, [...], Bushra Yasin Abohalawa, Nehad M. Alajez, Essam M. Abdelalim << Fewer
Published: 27 November 2025
2026, 13(4)
Rapid Communication | Open Access
Cis-regulation of FAM49A by a risk variant at 2p24 contributes to the genetic susceptibility of NSCL/P
Junyan Lin, Xiaofeng Li, Ji Mao, [...], Xinyu Zhang, Tingting Cheng, Yue Gao, Shu Lou, Dandan Li, Yongchu Pan << Fewer
Published: 30 September 2025
2026, 13(4)
Rapid Communication | Open Access
Ten-eleven translocation 2-mediated DNA demethylation plays a positive regulatory role in BMP9-induced osteogenic differentiation of mesenchymal stem cells
Connie Chen, Yi Zhu, Sarina Zhao, [...], Michelle Xiang, Chao Yu, Yan Peng, Yuting Liang, Jeffrey Baek, Longwei Qiao, Xiangyu Dong, Fangyi Yao, Jinglin Huang, Tong-Chuan He, Russell R. Reid, Jiaming Fan, Gregory Schimizzi, Sofia Bougioukli, Yong Xu, Changqi Luo << Fewer
Published: 28 February 2026
2026, 13(4)
REVIEW ARTICLE
Review Article | Open Access
Understanding nerve—tumor interactions: From basic biology to therapeutic innovation
Liangzhan Sun, Xia Li, Yaxuan Wang, [...], Jingxuan Wang, Renrui Xie, Ningyi Zhang, Zemin Zhang << Fewer
Published: 28 November 2025
2026, 13(4)
Review Article | Open Access
Lgr6+ cells in the biological system during homeostasis and injury
Han Li, Xiaoqi Guan, Yu Wang, Haidong Guo
Published: 24 September 2025
2026, 13(4)
Review Article | Open Access
Molecular mastery: Harnessing DNA technology for disease prevention
Giri Rajasekhar Dornadula, Ramakrishna Chilakala, Sadak Basha Shaik, [...], Pramod Kumar Meriga, Likhitha Chintha, Yeshwanth Gurugari, Kranthi Kumar D, Sameena Fatima Shaik, Sun Hee Cheong << Fewer
Published: 11 December 2025
2026, 13(4)
Review Article | Open Access
Mitochondrial transplantation in lung diseases: From mechanisms to application prospects
Haoneng Wu, Qiuran Zhao, Ying Zhao, [...], Jinguang Bai, Junxi Pan, Songling Huang << Fewer
Published: 18 September 2025
2026, 13(4)
Review Article | Open Access
The role and potential therapeutic intervention of cellular senescence in intervertebral disc degeneration
Yunbo Guan, Xuedong Bai, Chao Li, [...], Ziqiang Zhang, Qing He, Lin Chen, Yangli Xie, Zuqiang Wang << Fewer
Published: 24 September 2025
2026, 13(4)
Review Article | Open Access
MicroRNA-23b: Roles, functions and mechanisms in tumor
Xinyu Cai, Xueer Zheng, Zhenru Wang, [...], Jiahua Mao, Minhe Shen, Shanming Ruan << Fewer
Published: 18 September 2025
2026, 13(4)
Review Article | Open Access
ACSL4 in Alzheimer’s disease: Pathogenetic mechanisms and potential therapeutic targets
Yu Guo, Qingqing Jiang, Zhongya Gu, [...], Huan Cao, Chengchao Zuo, Yaqi Huang, Yu Song, Xiang Chen, Furong Wang << Fewer
Published: 18 September 2025
2026, 13(4)
Review Article | Open Access
Crosstalk between autophagy and ferroptosis in diabetes
Erlian Xie, Xuerong Wei, Zijun Zheng, [...], Qiuyi Yu, Mengqian Liu, Huihui Zhang, Ziwei Jiang, Yanbin Gao, Lei Yang << Fewer
Published: 10 November 2025
2026, 13(4)
Review Article | Open Access
Dendritic cell vaccines: Current research progress, challenges, and opportunities
Shilin Zhang, Shanzhao Mo, Wenxing Huang, [...], Dani Zhong, Xiaomei Yang, Shenxia Xie, Aiqun Liu, Fengzhen Mo, Xianing Huang, Heng Liu, Yangzi Li, Xiaoling Lu << Fewer
Published: 31 October 2025
2026, 13(4)
Review Article | Open Access
Context-dependent actions of STING pathway in colitis and associated colon cancer
Jiaorong Qu, Yajie Cai, Fanghong Li, [...], Yufei Li, Runping Liu << Fewer
Published: 18 September 2025
2026, 13(4)
Review Article | Open Access
FOXK2 gene expression in cancer: Potential regulatory mechanisms and clinical implications
Renata Ivo Vasconcelos, Luciana da Torre Carneiro, Raquel Ciuvalschi Maia, [...], Thaís Hancio, Gabriela Nestal de Moraes << Fewer
Published: 24 November 2025
2026, 13(4)
Review Article | Open Access
FOXA2 in islet biology: Orchestrating pancreatic development and glucose homeostasis
Ahmed K. Elsayed, Yusra Manzoor, Essam M. Abdelalim
Published: 09 December 2025
2026, 13(4)
Review Article | Open Access
Selenoproteins: Minute yet vital players governing cellular fate
Chaoyi Xia, Yifan Wu, Haoming Zhang, [...], Lang Qin, Yiren Hu, Caiyun Fu << Fewer
Published: 14 November 2025
2026, 13(4)
Review Article | Open Access
MYH9: Structure, functions, and therapeutic implications in cancer and genetic disorders
Shayan Emami, Amirreza Mazloomi, Fatemeh Ziadloo, [...], Shaghayegh Hosseinzadeh, Hassan Saeedi, Azin Khoshghiafeh, Mohammad Reza Ahmadifard << Fewer
Published: 11 December 2025
2026, 13(4)
Review Article | Open Access
KCNE gene family: From basic functions to diseases
Junshen Xiao, Xu Cheng, Dou Huang, [...], Shichao Wei, Zhaoyang Hu << Fewer
Published: 05 November 2025
2026, 13(4)
Review Article | Open Access
Receptor-mediated endocytosis by Megalin: Exploring its role in ligand interaction and disease mechanisms
Xian Zhang, Zhijun Zhang
Published: 24 October 2025
2026, 13(4)
Review Article | Open Access
Emerging roles of the metabolic regulator 3-hydroxy-3-methylglutaryl coenzyme-CoA reductase in human cancers: From biology to therapeutics
Wenfang Li, Jianxiong Xu, Yuxuan Long, [...], Han Zhang, Xiaojuan Rong, Zhengding Su << Fewer
Published: 19 November 2025
2026, 13(4)
Review Article | Open Access
Intra-tumoral microbiota: Key modulators of tumor immunity and therapeutic potential
Junju He, Hui Tan, Yanru Qiu, [...], Yuchao Dan, Qian Wan, Lan Li, Jie Wu, Qibin Song, Hongbin Chen, Bin Xu << Fewer
Published: 05 December 2025
2026, 13(4)
Review Article | Open Access
Role of circular RNAs in regulating toxicity induced by cancer therapies
Jiawen Xian, Javeria Qadir, Burton B. Yang, Ting Ye
Published: 11 December 2025
2026, 13(4)
Review Article | Open Access
Lactylation-driven therapeutic resistance in cancer: Mechanisms and therapeutic opportunities
Wanghao Zhang, Guanglong Huang, Woheng Tang, [...], Jiaxian Li, Jingxian Chen, Yaojiang Feng, Kaichen Li, Can Pan, Shunshen Li, Huayang Zhang, Rongxu Ye, Hao Long, Guo-zhong Yi << Fewer
Published: 17 November 2025
2026, 13(4)
FULL LENGTH ARTICLE
Full Length Article | Open Access
Immune checkpoint B7x promotes immune evasion and resistance to PD-1/PD-L1 blockade in bladder cancer
Marc C. Pulanco, Xiang Yu Zheng, Alexander Sankin, [...], Deyou Zheng, Xingxing Zang << Fewer
Published: 26 November 2025
2026, 13(4)
Full Length Article | Open Access
Blockade of co-inhibitory receptor immune checkpoint protein TIM3/CD366 augments the anti-cancer activity of CAR-T therapy in solid tumors: An ovarian cancer example
Binglan Zhang, Fuping Zhu, Song Wang, [...], Yong Huang, Shishi Yu, Shaorong Tian, Minmin Li, Pan Li, Qian Xue, Bingqiang Zhang << Fewer
Published: 11 December 2025
2026, 13(4)
Full Length Article | Open Access
Suppression of UCP2 alleviates leukemogenesis by enhancing branched-chain amino acids-induced oxidative stress via activating the PI3K/AKT/mTOR signaling pathway
Agida Okohi Innocent, Yajie Shen, Yixuan Gao, [...], Ruixin Sun, Kasimujiang aximujiang, Zizhen Xu, Jinke Cheng, Jiao Ma << Fewer
Published: 05 August 2025
2026, 13(4)
Full Length Article | Open Access
Identification of PLXNC1 as a novel biomarker for consensus molecular subtype 4 in colorectal cancer
Weiqi Wang, Mingxuan Zhou, Tiegang Li, [...], Wenqiang Gan, Silin Lv, Zheng Yan, Yufang Hou, Zifan Zeng, Liu Yang, Fang Zhang, Wenyi Zhao, Min Yang << Fewer
Published: 11 December 2025
2026, 13(4)
Full Length Article | Open Access
Impact of maternal lipopolysaccharide and polyinosinic-polycytidylic acid-induced infections on offspring cardiac development: Mitochondrial dysfunction and metabolic alterations
Yingrui Li, Willfredius Mugishagwe Rutahoile, Binquan Xiong, [...], Jianlin Du, Songbai Deng, Bin Liu, Xiaodong Jing, Huiping Yang, Yue Han, Qiang She << Fewer
Published: 08 October 2025
2026, 13(4)
Full Length Article | Open Access
Androgen receptor acts as the transcriptional repressor of the nuclear receptor LRH-1 via the androgen-driven chromatin looping conformation in prostate cancer
Wenxing You, Tiantian Gao, Haolong Li, [...], Daniel Hau Tak Lam, Wenjuan Xie, Lijia Xiao, Weijie Gao, Dinglan Wu, Junjian Wang, Yuliang Wang, Franky Leung Chan << Fewer
Published: 24 October 2025
2026, 13(4)
Full Length Article | Open Access
Elevated diurnal CD36 expression disrupts the bile acid synthesis rhythm leading to cholestatic liver injury and inflammation via the HMGCR/CYP7A1 axis
Yang Zhang, Mingyang Zhang, Shuning Fu, [...], Zhenyu Wang, Yunfei Zhao, Junhua Gong, Miao Chen, Nuo Zhang, Mengyue Chen, Xiong Z. Ruan, Yaxi Chen << Fewer
Published: 23 July 2025
2026, 13(4)
Full Length Article | Open Access
CD14+CXCL10+ monocytes are associated with peripheral immune network alterations in systemic juvenile idiopathic arthritis: From multiple centers
Qiang Luo, Jun Yang, Haiguo Yu, [...], Han Hao, Xinglin Wu, Xiwen Luo, Mingsheng Ma, Xi Yang, Zhiyong Zhang, Yunfei An, Xiaodong Zhao, Hongmei Song, Xuemei Tang << Fewer
Published: 19 November 2025
2026, 13(4)
Full Length Article | Open Access
PDK1 elevation was induced by epigenetic modifications of KDM3A and METTL16 to mediate TKI resistance and cancer development
Zhihao Zhou, Ruike Zhang, Zhaoyang Zhang, [...], Liyuan Zhang, Wei Wang, Wenjing Liu, Chunyang Zhang, Gen Lin, Weimiao Yu, Bo Xu, Lin Wang, Bing-Hua Jiang << Fewer
Published: 25 November 2025
2026, 13(4)
Full Length Article | Open Access
Deciphering the impact of SNAI1 gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics
Rattiyaporn Kanlaya, Kanokwan Nonthawong, Mueanchan Suntivichaya, [...], Sunisa Yoodee, Visith Thongboonkerd << Fewer
Published: 10 November 2025
2026, 13(4)
Full Length Article | Open Access
PANDORA-seq reveals human sperm sncRNA signature endowed with sperm quality assessment
Ruofan Huang, Yiting Yang, Wenlin Jiang, [...], Zheng Cao, Junchao Shi, Xiao-Ou Zhang, Yunfang Zhang << Fewer
Published: 18 August 2025
2026, 13(4)
Full Length Article | Open Access
ATOX1 overexpression mitigates copper homeostasis in microglia: Implications for Alzheimer's disease therapy
Fuxin Zhong, Jiani Wu, Zhangjing Deng, [...], Wuhan Yu, Jiaqi Song, Yingxi Chen, Weihua Yu, Yang Lü << Fewer
Published: 18 October 2025
2026, 13(4)
Full Length Article | Open Access
PAK1 inhibition synergistically enhances the anti-tumor efficacy of PARP inhibitors in ovarian cancers
Changying Li, Xinyan Li, Ming Gao, [...], Min Deng, Ye-Xiong Li, Zhenkun Lou << Fewer
Published: 21 October 2025
2026, 13(4)
Full Length Article | Open Access
Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury
Shuchao Wang, Yating Tan, Minghai Hu, [...], Meijuan Wang, Lu Liang, Xing Luo, Dan Chen, Bing Jiang, Ceshi Chen, Jufang Huang, Kun Xiong << Fewer
Published: 03 October 2025
2026, 13(4)
Full Length Article | Open Access
Sex-dependent impact of Il6 deficiency in Parkinson’s disease mice
Fangzheng Chen, Yufei Duan, Mengze Wang, [...], Zhaolin Liu, Jiayin Zhao, Guangchun Fan, Yongtao He, Hongtian Dong, Xiaoshuang Zhang, Rong Fang, Yunhe Zhang, Xin Yan, Chenye Shen, Xiwen Tang, Yuanyuan Ma, Mei Yu, Renyuan Zhou, Jian Fei, Fang Huang << Fewer
Published: 15 December 2025
2026, 13(4)