Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 12 Issue 5
Volume 12 Issue 5, September 2025
COMMENTARY
Commentary | Open Access
Elucidating the pathogenesis of bladder cancer through single-cell chromatin accessibility and DNA methylation analysis
Published: 03 March 2025
2025, 12(5): 101578
LETTER
Letter | Open Access
VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
Published: 22 January 2025
2025, 12(5): 101540
RAPID COMMUNICATION
Rapid Communication | Open Access
Clinical-molecular profiling of atypical GNAO1 patients: Novel pathogenic variants, unusual manifestations, and severe molecular dysfunction
Published: 09 January 2025
2025, 12(5): 101522
Rapid Communication | Open Access
lncRNA POU3F3 promotes osteosarcoma progression through GPX4-modulated ferroptosis by interaction with IGF2BP2 to facilitate NRF2 mRNA stability
Published: 12 October 2024
2025, 12(5): 101439
Rapid Communication | Open Access
FGFR1 inhibition by carvacrol: A novel strategy for oral squamous cell carcinoma therapy
Published: 04 December 2024
2025, 12(5): 101479
Rapid Communication | Open Access
RNA-seq identifies Amd1 as a regulator of hepatocyte proliferation via Skp2 during liver development and hepatocellular carcinoma progression in zebrafish
Published: 11 December 2024
2025, 12(5): 101486
Rapid Communication | Open Access
Establishment and characterization of an induced pluripotent stem cell line from a Japanese cystic fibrosis patient with homozygous 1540del10 CFTR mutation
Published: 25 December 2024
2025, 12(5): 101506
Rapid Communication | Open Access
New genetic insights into HIV-associated neurocognitive disorder and Alzheimer’s disease
Published: 26 February 2025
2025, 12(5): 101576
Rapid Communication | Open Access
Otof gene transfer in DFNB9 mice carrying human founder non-truncating alleles
Published: 06 March 2025
2025, 12(5): 101590
Rapid Communication | Open Access
Identification of a tertiary lymphoid structure (TLS)-related signature for ovarian cancer prognosis suggests a potential role of STAT5A in TLS maturation
Published: 04 January 2025
2025, 12(5): 101514
Rapid Communication | Open Access
MyoAAV-delivered sup-tRNA increases full-length dystrophin expression
Published: 03 May 2025
2025, 12(5): 101666
Rapid Communication | Open Access
Identification of a splice site mutation in IL2RG in a Chinese boy with X-linked severe combined immunodeficiency
Published: 04 January 2025
2025, 12(5): 101515
Rapid Communication | Open Access
Gene-based safety evaluation of molybdenum-containing biomaterials for cardiovascular and cerebrovascular diseases
Published: 05 January 2025
2025, 12(5): 101516
Rapid Communication | Open Access
circFOXO3 facilitated endothelial cell senescence and atherosclerosis through binding to HnRNPK
Published: 04 January 2025
2025, 12(5): 101517
Rapid Communication | Open Access
Integrating spatial transcriptomics and single-cell RNA-sequencing reveals epithelial cell alterations in benign prostatic hyperplasia following finasteride treatment
Published: 10 January 2025
2025, 12(5): 101526
Rapid Communication | Open Access
Identifying functional subtypes and common mechanisms of rheumatoid arthritis and systemic lupus erythematosus
Published: 10 January 2025
2025, 12(5): 101527
Rapid Communication | Open Access
HOPX inhibits skin cutaneous melanoma growth and induces macrophage M1 polarization
Published: 28 January 2025
2025, 12(5): 101550
Rapid Communication | Open Access
Deciphering the molecular landscape of oral squamous cell carcinoma: Novel biomarkers and therapeutic targets
Published: 03 February 2025
2025, 12(5): 101552
Rapid Communication | Open Access
Clinical impact of the TPM1 p.Tyr221Cys variant causing hypertrophic cardiomyopathy
Published: 26 February 2025
2025, 12(5): 101575
Rapid Communication | Open Access
Multi-omics analysis of epigenetic dysregulation reveals clinical heterogeneity and evaluates the immunotherapeutic potential of lung adenocarcinoma
Published: 20 February 2025
2025, 12(5): 101561
Rapid Communication | Open Access
Crowdedness imposes stress on tumor metastasis in Drosophila melanogaster
Published: 27 February 2025
2025, 12(5): 101574
Rapid Communication | Open Access
Glial subtype-specific modulation of disease pathogenesis in Drosophila models of ALS
Published: 08 April 2025
2025, 12(5): 101631
Rapid Communication | Open Access
Gene jigsaw: Decrypting the CPAMD8 puzzle in Chinese patients with anterior segment dysgenesis
Published: 16 January 2025
2025, 12(5): 101523
Rapid Communication | Open Access
Data-informed insights into sex differences in peripheral blood mononuclear cells from single-cell transcriptomics
Published: 08 January 2025
2025, 12(5): 101525
Rapid Communication | Open Access
A novel mutation in the KLHL17 gene is associated with neurodevelopmental disorders
Published: 10 January 2025
2025, 12(5): 101528
Rapid Communication | Open Access
Zinc finger transcription factor ZNF24 inhibits colorectal cancer growth and metastasis by suppressing MMP2 transcription
Published: 10 January 2025
2025, 12(5): 101529
Rapid Communication | Open Access
Sirolimus may improve bile excretion in ABCB11 mutants: A case report of a patient with bile salt export pump deficiency
Published: 15 January 2025
2025, 12(5): 101532
Rapid Communication | Open Access
Transcriptomic characterization of posterior capsule, anterior capsule, and femoral condylar tissue highlights tissue-specific microenvironments in knee osteoarthritis
Published: 10 January 2025
2025, 12(5): 101530
Rapid Communication | Open Access
A novel oridonin analogue, CYD0682, suppresses breast cancer growth, angiogenesis, and metastasis by inhibiting the ANGPTL4/MAPK signaling axis
Published: 08 May 2025
2025, 12(5): 101681
REVIEW ARTICLE
Review Article | Open Access
Ribosome biogenesis: A central player in liver diseases
Published: 04 January 2025
2025, 12(5): 101512
Review Article | Open Access
TET1: The epigenetic architect of clinical disease progression
Published: 04 January 2025
2025, 12(5): 101513
Review Article | Open Access
Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration
Published: 08 January 2025
2025, 12(5): 101518
Review Article | Open Access
Patient-derived xenograft models: Current status, challenges, and innovations in cancer research
Published: 08 January 2025
2025, 12(5): 101520
Review Article | Open Access
Landscape of metabolic alterations and treatment strategies in breast cancer
Published: 08 January 2025
2025, 12(5): 101521
Review Article | Open Access
Fibroblast growth factor 8: Multifaceted role in development and developmental disorder
Published: 10 January 2025
2025, 12(5): 101524
Review Article | Open Access
The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma
Published: 20 January 2025
2025, 12(5): 101534
Review Article | Open Access
Age-related and postmenopausal breast cancer progression and treatment management: The significance of pro-inflammatory cytokines and CXC chemokines
Published: 19 March 2025
2025, 12(5): 101606
Review Article | Open Access
Expression of LINE-1 elements is required for preimplantation development and totipotency
Published: 07 February 2025
2025, 12(5): 101555
Review Article | Open Access
Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy
Published: 19 March 2025
2025, 12(5): 101608
Review Article | Open Access
The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer
Published: 20 February 2025
2025, 12(5): 101567
Review Article | Open Access
Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma: A comprehensive review and recent advances
Published: 18 March 2025
2025, 12(5): 101605
Review Article | Open Access
Ribonucleases in Mendelian disease: Characterization and insight from model organisms
Published: 25 March 2025
2025, 12(5): 101613
Review Article | Open Access
Fusion genes in cancers: Biogenesis, functions, and therapeutic implications
Published: 20 January 2025
2025, 12(5): 101536
Review Article | Open Access
Tumor microenvironment in osteosarcoma: From cellular mechanism to clinical therapy
Published: 20 February 2025
2025, 12(5): 101569
FULL LENGTH ARTICLE
Full Length Article | Open Access
Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3
Published: 23 January 2025
2025, 12(5): 101545
Full Length Article | Open Access
Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines
Published: 18 March 2025
2025, 12(5): 101603
Full Length Article | Open Access
Galectin-3 in tumor-stromal cells enhances gemcitabine resistance in pancreatic adenocarcinoma by suppressing oxidative phosphorylation
Published: 29 May 2025
2025, 12(5): 101702
Full Length Article | Open Access
TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy
Published: 05 June 2025
2025, 12(5): 101707
Full Length Article | Open Access
Exogenous pyruvate is therapeutic against colitis by targeting cytosolic phospholipase A2
Published: 22 February 2025
2025, 12(5): 101571
Full Length Article | Open Access
Single-cell landscape of immunological responses in patients with juvenile idiopathic arthritis
Published: 03 March 2025
2025, 12(5): 101577
Full Length Article | Open Access
NKAPL suppresses NSCLC progression by enhancing the protein stability of TRIM21 and further inhibiting the NF-κB signaling pathway
Published: 11 March 2025
2025, 12(5): 101598
Full Length Article | Open Access
Amylin exacerbates tau pathology in the visual cortex of diabetic mice by impairing lysosomal activity
Published: 18 March 2025
2025, 12(5): 101602
Full Length Article | Open Access
Restriction of YWHAB-mediated YAP cytoplasmic retention is a novel mechanism underlying stemness maintenance and chemoresistance in ovarian cancer peritoneal metastasis
Published: 08 January 2025
2025, 12(5): 101519
Full Length Article | Open Access
The role of the aging process and related factor EMP1 in promoting progression of resectable pancreatic cancer
Published: 15 December 2024
2025, 12(5): 101490
Full Length Article | Open Access
XPR1 promotes ovarian cancer growth and regulates MHC-I through autophagy
Published: 27 December 2024
2025, 12(5): 101507
Full Length Article | Open Access
Genetically predicted blood metabolites mediate the association between immune cell characteristics and urolithiasis: A Mendelian randomization study and mediation analysis
Published: 28 January 2025
2025, 12(5): 101547
Full Length Article | Open Access
Single-cell sequencing reveals the expansion and diversity of T cell subsets in the bone marrow microenvironment of chronic myeloid leukemia
Published: 04 April 2025
2025, 12(5): 101626
Full Length Article | Open Access
Clinical relevance of loss-of-function mutations of NEMO/IKBKG
Published: 12 January 2025
2025, 12(5): 101531
Full Length Article | Open Access
Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway
Published: 21 February 2025
2025, 12(5): 101568
Full Length Article | Open Access
Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells
Published: 14 March 2025
2025, 12(5): 101601
Full Length Article | Open Access
Autophagy-induced NR2F1 activation promotes the apoptosis of lens epithelial cells and facilitates cataract-associated fibrosis through targeting STAT3
Published: 28 January 2025
2025, 12(5): 101549
Full Length Article | Open Access
miR-146b/Btg2 axis as a potential inducer of islet beta-cell decline during the progression of obesity to T2DM
Published: 02 April 2025
2025, 12(5): 101621
Erratum
Erratum | Open Access
Corrigendum to “Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia” [Genes & Dis 11 (2024) 413–429]
Published: 01 September 2025
2025, 12(5): 101579