Genes & Diseases Open Access Editors-in-Chief: Ailong Huang, Tong-Chuan He
Home Genes & Diseases All Issues Volume 12 Issue 3
Volume 12 Issue 3, May 2025
Cover
Back cover
Cover
Back cover
Contents(PDF)
57 articles
Previous Issue
|
Next Issue
LETTER
Letter | Open Access
Runx2 controls the osteogenic fate of growth plate chondrocytes
Daofu Zeng, Jiamin Yu, Ke Lu, [...], Dan Yi, Zhidao Xia, Ling Qin, Guozhi Xiao, Xiao Yang, Liping Tong, Di Chen << Fewer
Published: 01 May 2025
2025, 12(3): 101453
RAPID COMMUNICATION
Rapid Communication | Open Access
The abnormal splicing regulation network caused by synonymous mutations in FBN1 exon 39 leads to Marfan syndrome
Fudan Wu, Mingjie Li, Xuan Zhou, [...], Qianyun Wang, Yan’an Wu << Fewer
Published: 03 July 2024
2025, 12(3): 101371
Rapid Communication | Open Access
EWSR1-PSMC5 fusion gene variously activating autophagy in drug resistance of osteosarcoma: A novel gene fusion model report and mechanism research
Qing Pan, Wenbo Yang, Fuhua Huang, [...], Wei Wu, Zengwu Shao, Zhicai Zhang << Fewer
Published: 21 June 2024
2025, 12(3): 101358
Rapid Communication | Open Access
AUTS2 expression within mammalian lineage: A predictor of neural networks involved in autism spectrum disorders
Aude-Marie Lepagnol-Bestel, Yann Loe-Mie, Mounia Bensaid, Michel Simonneau
Published: 19 October 2024
2025, 12(3): 101440
Rapid Communication | Open Access
Prognostic significance and multidimensional roles of interferon regulatory factors in cancer biology: A comprehensive analysis
Guo Ji, Shuyuan Xian, Jiaqi Song, [...], Shiyu Mao, Man Pi, Qiongyi Huang, Xue Han, Jian Yin, Zan Wu, Runzhi Huang, Dongyan Han, Zhengyan Chang << Fewer
Published: 07 September 2024
2025, 12(3): 101426
Rapid Communication | Open Access
Construction of a prognostic model based on the cuproptosis-related genes in pancreatic cancer
Kaili Liao, Yuxin Fu, Shuman Guo, [...], Tingyi Qian, Feifei Teng, Yuhan Xu, Bing Sun, Hanqing Zhao, Jingyan Zhang, Ranhao Fan, Jie Gao, Xiaozhong Wang << Fewer
Published: 14 August 2024
2025, 12(3): 101391
Rapid Communication | Open Access
HOXB6 down-regulation induced by retinoic acid pathway repression leads to chondrocyte proliferation inhibition and apoptosis in microtia
Run Yang, Xin Chen, Siyi Wu, [...], Chenlong Li, Ying Chen, Yaoyao Fu, Aijuan He, Duan Ma, Jing Ma, Tianyu Zhang << Fewer
Published: 25 June 2024
2025, 12(3): 101367
Rapid Communication | Open Access
Role of PFKM lactylation in glycolysis regulation in endometrial cancer cells
Bin Wang, Jian Ma, Di Yang
Published: 30 August 2024
2025, 12(3): 101400
Rapid Communication | Open Access
Phosphorylation-related genes in lupus nephritis: Single-cell and machine learning insights
Lisha Mou, Zhihao Chen, Xinran Tian, [...], Yupeng Lai, Zuhui Pu, Meiying Wang << Fewer
Published: 06 August 2024
2025, 12(3): 101385
Rapid Communication | Open Access
A novel research model of clonal evolution in mantle cell lymphoma at the single-cell genomic level
Li Zhang, Yongsheng Liu, Liang Wang, [...], Li Wang, Li Zheng, Wei He, Li Yan, Lvsu Ye, Huidan Zhang, Junling Tang << Fewer
Published: 01 September 2024
2025, 12(3): 101406
Rapid Communication | Open Access
Utilization of cuproptosis-related lncRNAs to predict the prognosis of pancreatic cancer patients and explore their roles in immune cell infiltration and prognosis evaluation
Kaili Liao, Jinting Cheng, Xiajing Yu, [...], Ziqian Liu, Xue Zhang, Yuxin Fu, Wenyige Zhang, Jie Liu, Feifei Teng, Yuxuan Xie, Xiwen Yan, Gaoquan Cao, Bing Sun, Hanqing Zhao, Jingyan Zhang, Xiaozhong Wang << Fewer
Published: 06 September 2024
2025, 12(3): 101409
Rapid Communication | Open Access
Cross-talk between lactate metabolism and immunity reveals CEP55 as a potential regulator in the immunosuppressive microenvironment of hepatocellular carcinoma
Jie Li, Yuyuan Zhang, Jinhai Deng, [...], Siyuan Weng, Hui Xu, Yuhao Ba, Anning Zuo, Shutong Liu, Quan Cheng, Jian Zhang, Peng Luo, Zhen Li, Xinwei Han, Zaoqu Liu << Fewer
Published: 28 August 2024
2025, 12(3): 101399
Rapid Communication | Open Access
Targeting MUC1 with fisetin in oral squamous cell carcinoma
Qian Wang, Hongyan Zhang, Shuzhen Xiang, [...], Lan Zhang, Jiajia Fan, Zengyan Xu, Fengfei Zhao, Minda Liu, Yanshu Li, Wei Dai << Fewer
Published: 20 June 2024
2025, 12(3): 101357
Rapid Communication | Open Access
Tnni3k regulates cardiomyopathy and cardiac conduction disease through Nfatc1 signaling
Shi Ouyang, Yujuan Niu, Le Liu, [...], Qiaorong Yi, Wuming Qin, Hui Cao, Tao Liao, Rong Xiang, Yonghe Ding, Yun Deng << Fewer
Published: 13 November 2024
2025, 12(3): 101464
Rapid Communication | Open Access
ADAM8 inactivation modulates cellular component assembly gene expression in the mouse intervertebral disc
Ken Chen, Zuozhen Tian, Motomi Enomoto-Iwamoto, Yejia Zhang
Published: 19 November 2024
2025, 12(3): 101467
Rapid Communication | Open Access
Novel compound heterozygous TTN gene variants with additional potential contributory mutations in two sisters with severe scoliosis: A case report
Huaiyuan Wang, Shengjie Li, Weiyun Chen, Jianxiong Shen
Published: 03 December 2024
2025, 12(3): 101477
Rapid Communication | Open Access
Allele-specific methylation of the PSA promoter in prostate cells: A new translational marker for the differential diagnosis of prostate cancer
Mikhail Baryshev, Irina Maksimova, Ilona Sasoveca
Published: 09 December 2024
2025, 12(3): 101487
Rapid Communication | Open Access
Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling
Ailing Hao, Xiangyu Dong, Yannian Gou, [...], Aohua Li, Jiajia Li, Han Xiang, Saidur Rahaman, Yi Zhu, Hui Zhang, Wulin You, Guowei Shen, Changqi Luo, Ou Mei, Xingye Wu, Lewis L. Shi, Russell R. Reid, Tong-Chuan He, Jiaming Fan << Fewer
Published: 09 December 2024
2025, 12(3): 101484
Rapid Communication | Open Access
Assessment of the transcriptomic consequences and MAU2 protein levels in edited induced pluripotent stem cells with NIPBL pathogenic variants
Kévin Cassinari, Anne Rovelet-Lecrux, Céline Derambure, [...], Myriam Vezain, Sophie Coutant, Anne-Claire Richard, Nathalie Drouot, Juliette Coursimault, Gabriella Vera, Alice Goldenberg, Pascale Saugier-Veber, Camille Charbonnier, Gaël Nicolas << Fewer
Published: 06 August 2024
2025, 12(3): 101386
Rapid Communication | Open Access
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis
Eun Mi Song, Jahanzeb Saqib, Yang Hee Joo, [...], Zehra Ramsha, Chang Mo Moon, Sung-Ae Jung, Junil Kim << Fewer
Published: 30 October 2024
2025, 12(3): 101447
Rapid Communication | Open Access
A novel BCAT1 inhibitor bufalin sensitizes pancreatic cancer cells to chemotherapy
Wei Zhang, Yibao Fan, Milad Ashrafizadeh, [...], Dan Shi, Gautam Sethi, Yavuz Nuri Ertas, A.M. Abd El-Aty, Xianbin Zhang, Si Chen, Peng Gong << Fewer
Published: 24 December 2024
2025, 12(3): 101503
Rapid Communication | Open Access
Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells
Yang Wang, Naijipu Abuduaini, Wenjuan Liu, [...], Yuanjun Song, Zunping Ke, Xilong Wang, Wei Jiao, Si Chen, Xianhua Lin, Weiwei Yu, Weiqiang Lu, Bo Feng, Jiacheng He << Fewer
Published: 20 June 2024
2025, 12(3): 101356
Rapid Communication | Open Access
Hub genes identification for diagnosing Alzheimer's disease in patients with Crohn's disease
Pei Liu, Xiaoying Yao, Hongyan Wang
Published: 30 November 2024
2025, 12(3): 101476
Rapid Communication | Open Access
In vivo consequences of varying degrees of OTOA alteration elucidated using knock-in mouse models and pseudogene contamination-free long-read sequencing
Ju Ang Kim, Bong Jik Kim, Chung Lee, [...], Go Hun Seo, Hane Lee, Jin Hee Han, Ava Niazi, Joosang Park, Byung Yoon Choi, Sungjin Park << Fewer
Published: 18 January 2025
2025, 12(3): 101533
REVIEW ARTICLE
Review Article | Open Access
Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease
Shiying Sun, Wen Wang
Published: 16 March 2024
2025, 12(3): 101267
Review Article | Open Access
Cardiomyocyte proliferation: Advances and insights in macrophage-targeted therapy for myocardial injury
Tao Wang, Xueyao Wang, Weibin Ren, [...], Zeyu Sun, Yanhui Zhang, Nanping Wu, Hongyan Diao << Fewer
Published: 19 May 2024
2025, 12(3): 101332
Review Article | Open Access
The subventricular zone structure, function and implications for neurological disease
Kaishu Li, Yin Zheng, Shubing Cai, [...], Zhiming Fan, Junyi Yang, Yuanrun Liu, Shengqi Liang, Meihui Song, Siyuan Du, Ling Qi << Fewer
Published: 26 August 2024
2025, 12(3): 101398
Review Article | Open Access
Transcription factors, metabolic dysfunction-associated fatty liver disease, and therapeutic implications
Shuwei Hu, Yingjie Ai, Chencheng Hu, [...], Fathima N. Cassim Bawa, Yanyong Xu << Fewer
Published: 05 July 2024
2025, 12(3): 101372
Review Article | Open Access
The crosstalk between non-coding RNAs and oxidative stress in cancer progression
Qiqi Sun, Xiaoyong Lei, Xiaoyan Yang
Published: 10 April 2024
2025, 12(3): 101286
Review Article | Open Access
The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis
Yinrui Li, Bo Wang, Yichao Zheng, [...], Huiqin Kang, Ang He, Lijuan Zhao, Ningjie Guo, Hongmin Liu, Adil Mardinoglu, M.A.A. Mamun, Ya Gao, Xiaobing Chen << Fewer
Published: 15 April 2024
2025, 12(3): 101307
Review Article | Open Access
Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
Shengnan Hu, Xueying Tang, Fangrui Zhu, [...], Chen Liang, Sa Wang, Hongjie Wang, Peifeng Li, Yuzhen Li << Fewer
Published: 28 March 2024
2025, 12(3): 101282
Review Article | Open Access
Coding circular RNA in human cancer
Yuan Lin, Yawen Wang, Lixin Li, Kai Zhang
Published: 14 June 2024
2025, 12(3): 101347
Review Article | Open Access
Treating human cancer by targeting EZH2
Mengfei Xu, Chunyan Xu, Rui Wang, [...], Qing Tang, Qichun Zhou, Wanyin Wu, Xinliang Wan, Handan Mo, Jun Pan, Sumei Wang << Fewer
Published: 25 April 2024
2025, 12(3): 101313
Review Article | Open Access
Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality
Qianqian Guo, Hai Qin, Zelong Chen, [...], Wenzhou Zhang, Lufeng Zheng, Tingting Qin << Fewer
Published: 17 April 2024
2025, 12(3): 101311
Review Article | Open Access
tRNA-derived small RNAs in digestive tract diseases: Progress and perspectives
Mingrui Liu, Xiaojun Zhuang, Haiqing Zhang, [...], Weidong Ji, Gang Yuan << Fewer
Published: 13 May 2024
2025, 12(3): 101326
Review Article | Open Access
Molecular mechanism of tumor-infiltrating immune cells regulating endometrial carcinoma
Silu Ding, Yingying Hao, Yue Qi, [...], Heng Wei, Jin Zhang, Hui Li << Fewer
Published: 05 November 2024
2025, 12(3): 101442
Review Article | Open Access
The role of lncRNAs in AKI and CKD: Molecular mechanisms, biomarkers, and potential therapeutic targets
Minhui Zheng, Zixuan Yang, Lei Shi, [...], Liyuan Zhao, Kelan Liu, Naping Tang << Fewer
Published: 30 December 2024
2025, 12(3): 101509
Review Article | Open Access
Differences between lung adenocarcinoma and lung squamous cell carcinoma: Driver genes, therapeutic targets, and clinical efficacy
Yue Shen, Jie-Qi Chen, Xiang-Ping Li
Published: 11 July 2024
2025, 12(3): 101374
Review Article | Open Access
Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells
Wen Yan, Shasha Xiang, Jianbo Feng, Xuyu Zu
Published: 03 June 2024
2025, 12(3): 101341
Review Article | Open Access
Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications
Dian Hu, Zerui Zhang, Yijun Wang, [...], Siwen Li, Jiaqian Zhang, Zhangfan Wu, Mengyu Sun, Junqing Jiang, Danfei Liu, Xiaoyu Ji, Shuai Wang, Yufei Wang, Xiangyuan Luo, Wenjie Huang, Limin Xia << Fewer
Published: 23 August 2024
2025, 12(3): 101394
Review Article | Open Access
Research progress on the use of traditional Chinese medicine to treat diseases by regulating ferroptosis
Shuai Liu, Xianzhen Yang, Sanxia Zheng, [...], Changjing Chen, Lei Qi, Xiangdong Xu, Denglu Zhang << Fewer
Published: 06 November 2024
2025, 12(3): 101451
FULL LENGTH ARTICLE
Full Length Article | Open Access
Sonic Hedgehog potentiates BMP9-induced osteogenic differentiation of mesenchymal stem cells
Lulu Zhang, Caixia Ji, Ziyun Li, [...], Habu Jiwa, Zhou Xie, Xiaoji Luo, Jinyong Luo << Fewer
Published: 14 April 2024
2025, 12(3): 101308
Full Length Article | Open Access
Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis
Kai Huang, Linyu Yang, Yue Ma, [...], Lijian Cao, Suwen Li, Zhenzhen Zhao, Jianwu Zhou, Shan Wang << Fewer
Published: 03 January 2025
2025, 12(3): 101511
Full Length Article | Open Access
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease
Mingfeng Hu, Qiling Xu, Fang Zhang, [...], Karen F. Buckland, Yelei Gao, Weixia Du, Yuan Ding, Lina Zhou, Xiulian Sun, Lijia Ma, Zhiyong Zhang, Xuemei Tang, Xiaodong Zhao, Adrian J. Thrasher, Yunfei An << Fewer
Published: 06 November 2024
2025, 12(3): 101445
Full Length Article | Open Access
EGFR-mediated crosstalk between vascular endothelial cells and hepatocytes promotes Piezo1-dependent liver regeneration
Yuelei Hu, Guifang Du, Chao Li, [...], Rui Wang, Juan Liu, Yunfang Wang, Jiahong Dong << Fewer
Published: 08 May 2024
2025, 12(3): 101321
Full Length Article | Open Access
SPP1+ macrophages in colorectal cancer: Markers of malignancy and promising therapeutic targets
Zhenyu Xie, Gaozan Zheng, Liaoran Niu, [...], Kunli Du, Ruikai Li, Hanjun Dan, Lili Duan, Hongze Wu, Guangming Ren, Xinyu Dou, Songchen Dai, Fan Feng, Jian Zhang, Jianyong Zheng << Fewer
Published: 30 May 2024
2025, 12(3): 101340
Full Length Article | Open Access
The scRNA-sequencing landscape of pancreatic ductal adenocarcinoma revealed distinct cell populations associated with tumor initiation and progression
Ying Wang, Zhouliang Bian, Lichao Xu, [...], Guangye Du, Zihao Qi, Yanjie Zhang, Jiang Long, Wentao Li << Fewer
Published: 10 May 2024
2025, 12(3): 101323
Full Length Article | Open Access
Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma
Guichuan Lai, Biao Xie, Cong Zhang, [...], Xiaoni Zhong, Jielian Deng, Kangjie Li, Hui Liu, Yuan Zhang, Anbin Liu, Yi Liu, Jie Fan, Tianyi Zhou, Wei Wang, Ailong Huang << Fewer
Published: 27 November 2024
2025, 12(3): 101471
Full Length Article | Open Access
Isoleucyl-tRNA synthetase 2 promotes pancreatic ductal adenocarcinoma proliferation and metastasis by stabilizing β-catenin
Yixun Jin, Xinyang Huang, Zhuoxin Wang, [...], Berik Kouken, Qi Wang, Lifu Wang << Fewer
Published: 24 July 2024
2025, 12(3): 101382
Full Length Article | Open Access
HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression
Jiacheng Zhong, Shuang Shi, Wen Peng, [...], Hongjuan Cui, Xiaochuan Sun << Fewer
Published: 12 September 2024
2025, 12(3): 101433
Full Length Article | Open Access
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization
Huijun Qiu, Jiang Liu, Jingyi You, [...], Ou Zhou, Chang Hao, Yi Shu, Deyu Ma, Wenjing Zou, Linghuan Zhang, Enmei Liu, Zhengxiu Luo, Luo Ren, Gang Geng, Lin Zou, Danyi Peng, Zhou Fu << Fewer
Published: 15 February 2024
2025, 12(3): 101244
Full Length Article | Open Access
The genomic and epigenomic landscape of iridocorneal endothelial syndrome
Yaoming Liu, Gen Li, Jiaxuan Jiang, [...], Sujie Fan, Lan Lu, Ting Wang, Guigang Li, Wenzong Zhou, Xuequn Liu, Yingjie Li, Hong Sun, Liang Liang, Yuhong Tang, Yang Chen, Jianjun Gu, Fei Li, Xiuli Fang, Tao Sun, Aiguo Lv, Yayi Wang, Peiyuan Wang, Tao Wen, Jiayu Deng, Yuhong Liu, Mingying Lai, Jingni Yu, Danyan Liu, Hua Wang, Meizhu Chen, Li Li, Xiaodan Huang, Jingming Shi, Xu Zhang, Kang Zhang, Lingyi Liang, Xiulan Zhang << Fewer
Published: 06 November 2024
2025, 12(3): 101448
Full Length Article | Open Access
Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria
Jingyi Su, Yongdong Pan, Fengbo Zhong, [...], Yi Zhong, Jiaxin Huang, Shengnan Liu, Kaiyuan Wang, Kai Lin, Xiangchen Gu, Dali Li, Qihui Wu, Hongquan Geng, Yuting Guan, Guofeng Xu << Fewer
Published: 29 November 2024
2025, 12(3): 101472
Full Length Article | Open Access
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response
Hao Li, Kailun Yu, Xiandan Zhang, [...], Jiawen Li, Huilong Hu, Xusheng Deng, Siyu Zeng, Xiaoning Dong, Junru Zhao, Yongyou Zhang << Fewer
Published: 16 May 2024
2025, 12(3): 101327
Full Length Article | Open Access
Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells
Jing Zou, Chengcheng Du, Senrui Liu, [...], Piao Zhao, Shengqiang Gao, Bowen Chen, Xiangdong Wu, Wei Huang, Zhenglin Zhu, Junyi Liao << Fewer
Published: 20 May 2024
2025, 12(3): 101336
Full Length Article | Open Access
IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis
Xinyue Li, Hong Zhang, Fan Yu, [...], Shuting Xie, Tongyu Wang, Rong Zhang, Guangzhong Xu, Liang Wang, Yeping Huang, Cheng Hu << Fewer
Published: 20 May 2024
2025, 12(3): 101333
Full Length Article | Open Access
Landscape of chimeric RNAs in COVID-19 patient blood
Samuel Haddox, Ping Wu, Sandeep Singh, [...], Fujun Qin, Jack Engel, Andrea Kian, Syed Ahmad, Hui Li, Peng Wu << Fewer
Published: 06 June 2024
2025, 12(3): 101348