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3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids

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Abstract

Nanocatalytic medicine triggering in situ catalytic reactions has been considered as a promising strategy for tumor-selective therapeutics. However, the targeted distribution of nanocatalysts was still low, considering the absence of targeting propulsion capability. Here, encouraged by the fast-developing controllable microrobotics for targeting delivery, a sunflower-like nanocatalytic active swarm (SNCAS) controlled by a three-dimensional (3D) magnetic field was proposed for synergistic tumor-selective and magnetic-actively tumor-targeting therapeutics. Furthermore, a patient-derived renal cancer cell 3D organoid was utilized for the verification of the effective tumor therapeutic outcomes. Under the targeted control of 3D magnetic field, the multiple cascade catalytic efficiency of SNCAS based on Fenton reaction was evaluated, resulting in efficient tumor cell apoptosis and death. For the patient-derived organoid treatment, the SNCAS presented significant lethality toward 3D organoid structure to induce cell apoptosis with the collapse of organoid morphology. The targeting efficiency was further enhanced under the magnetic-controllable of SNCAS. Overall, empowered by the magnetic control technology, the synergistic therapeutic strategy based on controllable swarm combined active targeting and tumor-specific catalytic nanomedicine has provided a novel way for advanced cancer therapy. Meanwhile, 3D patient-derived organoids were proved as a powerful tool for the effectiveness verification of nanocatalytic medicine.

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Acknowledgements

This work was supported by the National Key R&D Program of China (No. 2018YFA0901700), the National Natural Science Foundation of China (Nos. 21878173, 52175273, and 82072837), the 111 Project (No. B17026), and a grant from the Institute Guo Qiang, Tsinghua University (No. 2021GQG1016).

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Author notes

  1. Dong Liu, Ruirui Guo, and Shuangshuang Mao contributed equally to this work.

Authors and Affiliations

  1. Key Laboratory of Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China

    Dong Liu, Ruirui Guo, Yanjie Huang, Bin Wang, Zijian Wu, Xuanjie Xia & Yuan Lu

  2. Tianjin Industrial Microbiology Key Laboratory, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China

    Dong Liu, Ruirui Guo, Yanjie Huang & Jian Dong

  3. Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China

    Shuangshuang Mao & Yuan Pang

  4. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China

    Yu Xin

  5. National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

    Ruiyang Xie & Jianzhong Shou

  6. Biomanufacturing Center, Dept. of Mechanical Engineering, Tsinghua University, Beijing, 100084, China

    Wei Sun

Authors
  1. Dong Liu
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  13. Yuan Pang
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Correspondence to Yuan Pang or Yuan Lu.

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Liu, D., Guo, R., Mao, S. et al. 3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids. Nano Res. 16, 1021–1032 (2023). https://doi.org/10.1007/s12274-022-4851-z

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  • DOI: https://doi.org/10.1007/s12274-022-4851-z

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