RT Journal Article A1 Zhaokui Jin,Penghe Zhao,Wanjun Gong,Wenjiang Ding,Qianjun He; AD 氢科学中心, 中国 ; 生物医学工程学院, 中国 ; 生物医学工程学院, 中国 ; 生物医学工程学院, 中国 ; 氢科学中心, 中国 ; 氢科学中心, 中国 ; 生物医学工程学院, 中国 T1 Fe-porphyrin: A redox-related biosensor of hydrogen molecule YR 2023 IS 2 vo 16 OP 2020-OP 2025 K1 catalysis;carbon monoxide;porphyrin;hydrogen molecule;molecular mechanism;molecular target;hydrogen medicine AB Hydrogen molecule (H2) exhibits broad-spectrum but microenvironment-dependent biomedical effects in varied oxidation stress-related diseases, but its molecular mechanism is unclear and its targeting molecule is unknown so far. Herein, we originally reveal that Fe-porphyrin is a H2-targeted molecule. We have demonstrated that the oxidized Fe-porphyrin in both free and protein-confining states can self-catalyze the hydrogenation/reduction by reacting with H2 to catalytically scavenge ∙OH, and can also catalytically hydrogenate to reduce CO2 into CO in the hypoxic microenvironment of in vitro simulation and in vivo tumor, confirming that Fe-porphyrin is a redox-related biosensor of H2 and H2 is an upstream signaling molecule of CO. These discoveries are favorable for deep understanding and exploration of profound biomedical effects of H2, and helpful for development of innovative drugs and hydrogen energy/agricultural materials. SN 1998-0124 LA EN