RT Journal Article A1 Tongxu Gu,Tong Chen,Liang Cheng,Xiang Li,Gaorong Han,Zhuang Liu; AD 材料科学与工程学院,硅材料国家重点实验室, 中国 ; 材料科学与工程学院,硅材料国家重点实验室, 中国 ; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, 中国 ; 材料科学与工程学院,硅材料国家重点实验室, 中国 ; 材料科学与工程学院,硅材料国家重点实验室, 中国 ; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, 中国 T1 Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy YR 2020 IS 8 vo 13 OP 2209-OP 2215 K1 mesoporous silica;chemotherapy;platinum nanoparticles;electrodynamic therapy AB Electrodynamic therapy (EDT) is a conceptually new cancer treatment approach recently proposed by our group. During EDT, the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles (PtNPs) to produce reactive oxygen species (ROS) under the direct current (DC) or square-wave alternating current (AC) electric field. To further extend the potential of EDT, we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin (DOX) for synergistic electrodynamic-chemotherapy. Such silica-based nanocomposites could enable homogenous killing of large-sized tumors (over 500 mm3) and realize remarkable tumor destruction efficacy at a relatively low quantity of electricity. To our best knowledge, this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform, openning a new dimension for the design of other EDT-based anticancer strategies. SN 1998-0124 LA EN