RT Journal Article A1 Yaling Hu,Zhihua Gao; AD 第二附属医院神经生物学系、神经外科、教育部生物医学工程重点实验室, 中国 ; NHC和CAMS医学神经生物学重点实验室,教育部脑科学与脑医学院脑研究与脑机集成前沿科学中心, 中国 ; 第二附属医院神经生物学系、神经外科、教育部生物医学工程重点实验室, 中国 ; NHC和CAMS医学神经生物学重点实验室,教育部脑科学与脑医学院脑研究与脑机集成前沿科学中心, 中国 T1 The role of purinergic signaling in microglial responses YR 2021 IS 1 vo 1 OP 46-OP 58 K1 microglia;purinergic signaling;adenosine triphosphate (ATP);purinergic type 1 (P1) receptors;purinergic type 2 (P2) receptors AB Microglia, the primary immune cells in the central nervous system (CNS), are key to the maintenance of homeostasis in the brain parenchyma. In the intact brain, microglia continuously survey the microenvironment with ramified processes. Upon disease and/or damage, they rapidly convert into an amoeboid morphology, move toward the injury, and release cytokines to repair damage or clear debris. Purinergic signaling plays an important role in regulating microglial dynamics and immune responses. Specific purinergic receptors have been shown to participate in different aspects of microglial responses in the normal and diseased brains. In this review, we focus on the role of purinergic signaling-mediated microglial responses under physiological and pathological conditions. SN 2709-1325 LA EN