{Reference Type}: Journal Article {Title}: NMDARs regulate the excitatory-inhibitory balance within neural circuits {Author}: Zhou, Liang; Sun, Xiaohui; Jingjing, Duan {Journal}: Brain Science Advances {ISBN/ISSN}: 2096-5958 {Year}: 2023 {Volume}: 9 {Issue}: 1 {Pages}: 3-14 {DOI}: 10.26599/BSA.2022.9050020 {Keywords}: NMDAR {Keywords}: AMPAR {Keywords}: GABAAR {Keywords}: excitatory-inhibitory balance {Keywords}: neurological disorders {Abstract}: Excitatory-inhibitory (E/I) balance is essential for normal neural development, behavior and cognition. E/I imbalance leads to a variety of neurological disorders, such as autism and schizophrenia. NMDA receptors (NMDARs) regulate AMPAR-mediated excitatory and GABAAR-mediated inhibitory synaptic transmission, suggesting that NMDARs play an important role in the establishment and maintenance of the E/I balance. In this review, we briefly introduced NMDARs, AMPARs and GABAARs, summarized the current studies on E/I balance mediated by NMDARs, and discussed the current advances in NMDAR-mediated AMPAR and GABAAR development. Specifically, we analyzed the role of NMDAR subunits in the establishment and maintenance of E/I balance, which may provide new therapeutic strategies for the recovery of E/I imbalance in neurological disorders. {URL}: https://www.sciopen.com/article/10.26599/BSA.2022.9050020 {Language}: en