@article{Zhou2023, author = {Liang Zhou and Xiaohui Sun and Jingjing Duan}, title = {NMDARs regulate the excitatory-inhibitory balance within neural circuits}, year = {2023}, journal = {Brain Science Advances}, volume = {9}, number = {1}, pages = {3-14}, keywords = {NMDAR, AMPAR, GABAAR, excitatory-inhibitory balance, neurological disorders}, url = {https://www.sciopen.com/article/10.26599/BSA.2022.9050020}, doi = {10.26599/BSA.2022.9050020}, abstract = {Excitatory-inhibitory (E/I) balance is essential for normal neural development, behavior and cognition. E/I imbalance leads to a variety of neurological disorders, such as autism and schizophrenia. NMDA receptors (NMDARs) regulate AMPAR-mediated excitatory and GABAAR-mediated inhibitory synaptic transmission, suggesting that NMDARs play an important role in the establishment and maintenance of the E/I balance. In this review, we briefly introduced NMDARs, AMPARs and GABAARs, summarized the current studies on E/I balance mediated by NMDARs, and discussed the current advances in NMDAR-mediated AMPAR and GABAAR development. Specifically, we analyzed the role of NMDAR subunits in the establishment and maintenance of E/I balance, which may provide new therapeutic strategies for the recovery of E/I imbalance in neurological disorders.} }