TY - JOUR AU - Zhu, Wenjun AU - Yang, Yu AU - Jin, Qiutong AU - Chao, Yu AU - Tian, Longlong AU - Liu, Jingjing AU - Dong, Ziliang AU - Liu, Zhuang PY - 2019 TI - Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy JO - Nano Research SN - 1998-0124 SP - 1307 EP - 1312 VL - 12 IS - 6 AB - Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D NMOFs could be labeled with a diagnostic radioisotope, 99mTc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection. While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT, such 2D NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D NMOFs for nanomedicine applications. UR - https://doi.org/10.1007/s12274-018-2242-2 DO - 10.1007/s12274-018-2242-2