TY  - JOUR
AU  - Sheng, Yufei
AU  - Yang, Lulu
AU  - Wang, Boyang
AU  - Hu, Wentao
AU  - Zhou, Chengwei
AU  - Gong, Zhaohui
PY  - 2026
TI  - Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy
JO  - Cancer Biology & Medicine
SN  - 2095-3941
SP  - 1361
EP  - 1379
VL  - 23
IS  - 10
AB  - Non-coding RNAs (ncRNAs) regulate antitumor immunity but clinical use is hindered by instability, poor specificity, and immunogenic risk. Lipid nanoparticles (LNPs) offer a promising delivery solution due to biocompatibility, a modifiable surface, and efficient ncRNA encapsulation. Preclinical and early clinical studies have demonstrated the efficacy of LNP-ncRNA therapies in various cancers, including respiratory, digestive, and neurologic malignancies, and in cancer immunotherapy. This review evaluates engineered LNPs administered via different routes, explains the mechanisms that promote antitumor effects, and highlights advances in overcoming delivery barriers to enhance immunotherapy. Current limitations of engineered LNPs are also analyzed, essential translational challenges are identified, and future directions to facilitate the clinical application of LNP-based ncRNA therapies are suggested.
UR  - https://doi.org/10.20892/j.issn.2095-3941.2025.0825
DO  - 10.20892/j.issn.2095-3941.2025.0825