@article{Wang2026, 
author = {Qingli Wang and Yun Chen and Xuelong Liu and V. Wee Yong and Mengzhou Xue},
title = {Microglia-neuron crosstalk in intracerebral hemorrhage: from neuroimmunomodulation to neurorepair},
year = {2026},
journal = {Brain Hemorrhages},
volume = {7},
number = {5},
pages = {247-249},
keywords = {ICH, Microglia-neuron crosstalk, Neuroimmunomodulation, Neurorepair, Cell–surface signaling axes},
url = {https://www.sciopen.com/article/10.1016/j.hest.2026.06.001},
doi = {10.1016/j.hest.2026.06.001},
abstract = {Intracerebral hemorrhage (ICH) remains a devastating disease with high mortality and disability rates, yet effective therapeutic strategies are still limited. Emerging evidence has highlighted that the dynamic crosstalk between microglia and neurons plays a central role in both secondary brain injury and subsequent neural repair. We briefly summarize recent advances regarding how neurons actively modulate microglial phenotypes via soluble mediators and cell–surface signaling axes . We also discuss the dual role of microglia in hematoma clearance, inflammation resolution and tissue remodeling. We propose that targeting microglia–neuron interactions may represent a promising strategy for neuroimmunoregulation and neurorepair after ICH.}
}