TY  - JOUR
AU  - Wang, Qingli
AU  - Chen, Yun
AU  - Liu, Xuelong
AU  - Yong, V. Wee
AU  - Xue, Mengzhou
PY  - 2026
TI  - Microglia-neuron crosstalk in intracerebral hemorrhage: from neuroimmunomodulation to neurorepair
JO  - Brain Hemorrhages
SN  - 2589-238X
SP  - 247
EP  - 249
VL  - 7
IS  - 5
AB  - Intracerebral hemorrhage (ICH) remains a devastating disease with high mortality and disability rates, yet effective therapeutic strategies are still limited. Emerging evidence has highlighted that the dynamic crosstalk between microglia and neurons plays a central role in both secondary brain injury and subsequent neural repair. We briefly summarize recent advances regarding how neurons actively modulate microglial phenotypes via soluble mediators and cell–surface signaling axes . We also discuss the dual role of microglia in hematoma clearance, inflammation resolution and tissue remodeling. We propose that targeting microglia–neuron interactions may represent a promising strategy for neuroimmunoregulation and neurorepair after ICH.
UR  - https://doi.org/10.1016/j.hest.2026.06.001
DO  - 10.1016/j.hest.2026.06.001