@article{LI2026, 
author = {Xiang LI and Ke-Ke CHEN and Xin TIAN and Yong-Zhi ZHENG and Ben-Shan ZHANG and Hua JIANG and Li-Hua YANG and Hui-Rong MAI and Hong-Gui XU and Xiao-Qin FENG and Xiang-Ling HE},
title = {Childhood acute myeloid leukemia with TLS::ERG fusion gene: a clinical analysis of 12 cases},
year = {2026},
journal = {Chinese Journal of Contemporary Pediatrics},
volume = {28},
number = {9},
pages = {1099-1105},
keywords = {Acute myeloid leukemia, TLS::ERG fusion gene, C-HUANAN-AML-15 protocol, Chromosomal translocation, Child},
url = {https://www.sciopen.com/article/10.7499/j.issn.1008-8830.2601123},
doi = {10.7499/j.issn.1008-8830.2601123},
abstract = {ObjectiveTo investigate the clinical characteristics and prognosis of pediatric acute myeloid leukemia (AML) with TLS::ERG fusion gene.Methods Clinical data from multiple pediatric hematology centers in South China were retrospectively reviewed for the period September 2015 to October 2025. Cases harboring the TLS::ERG fusion gene were identified and analyzed.ResultsAmong 875 children with AML, 12 (1.4%) were TLS::ERG positive; there were 6 males and 6 females, with a median age of 88 months. The complete remission rate after 2 induction courses was 83% (10/12). Six patients relapsed, yielding a relapse rate of 50% (6/12). Four patients remained disease-free, six died after relapse, and two were lost to follow-up. The 5-year overall survival and event-free survival were 38.4% (95%CI: 16.8%-87.8%) and 30.0% (95%CI: 12.0%-74.7%), respectively.ConclusionsPediatric AML with TLS::ERG fusion is rare, shows a high early induction remission rate, but has a high relapse rate and poor prognosis.}
}