@article{DING2026, 
author = {Zhi-Heng DING and Li-Li YANG and Qi-Hong LIN and Dong-Yan CHEN and Ming-Jing LUO and Chun-Jing WANG and Xiao-Hui ZHOU and Yue LI and Qian ZHANG and Yu ZHANG and Chun-Lan YANG and Fei-Qiu WEN and Si-Xi LIU},
title = {Clinical value of plasma Epstein-Barr virus DNA monitoring in lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation in children},
year = {2026},
journal = {Chinese Journal of Contemporary Pediatrics},
volume = {28},
number = {9},
pages = {1106-1112},
keywords = {Post-transplant lymphoproliferative disorder, Epstein-Barr virus, Allogeneic hematopoietic stem cell transplantation, Child},
url = {https://www.sciopen.com/article/10.7499/j.issn.1008-8830.2512017},
doi = {10.7499/j.issn.1008-8830.2512017},
abstract = {ObjectiveTo evaluate the diagnostic value of plasma Epstein-Barr virus (EBV) DNA load and the duration of EBV DNAemia for post-transplant lymphoproliferative disorders (PTLD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children.Methods Clinical data of children who underwent allo-HSCT at Shenzhen Children's Hospital from January 2016 to December 2023 and had plasma EBV-DNA positivity after transplantation were retrospectively analyzed. According to the occurrence of PTLD, patients were divided into a PTLD group (n=53) and a non-PTLD group (n=376).ResultsA total of 429 children were included; 53 (12.4%) developed PTLD, with a median time to PTLD diagnosis of 85 days post-transplant. Peak plasma EBV-DNA load and the duration of EBV DNAemia were both significantly higher in the PTLD group than in the non-PTLD group (both P<0.001). Receiver operating characteristic curve analysis for predicting PTLD showed that using 2250 copies/mL as the cut-off for plasma EBV-DNA load yielded the highest Youden index (sensitivity 0.811; specificity 0.699), while using 12.5 days as the cut-off for the duration of EBV DNAemia yielded the highest Youden index (sensitivity 0.868; specificity 0.870).ConclusionsDynamic monitoring of plasma EBV-DNA load and the duration of EBV DNAemia helps predict the occurrence of PTLD and facilitates early intervention in children after allo-HSCT.}
}