@article{Jiang2026, 
author = {Xingting Jiang and Wenling Fang and Panpan Hu and Rong Yu and Jing Ma and Ning Wang and Tianyu Wu and Lin Ye and Wenhui Ruan and Zhaojun Li and Lin Jin},
title = {Fetal Ventricular-arterial Coupling: Development, Physiology, and Ultrasonographic Advances},
year = {2026},
journal = {Advanced Ultrasound in Diagnosis and Therapy},
volume = {10},
number = {3},
pages = {158-168},
keywords = {Fetus, Ventricular-arterial coupling, Cardiovascular development, Echocardiography},
url = {https://www.sciopen.com/article/10.26599/AUDT.2026.250112},
doi = {10.26599/AUDT.2026.250112},
abstract = {Ventricular-arterial coupling (VAC) is a key determinant of cardiovascular function, reflecting the interaction between cardiac pump performance and arterial load, and plays a crucial role during fetal development. The fetal cardiovascular system undergoes a continuous process from cardiac tube formation and chamber septation to vascular remodeling, providing the structural and functional basis for postnatal circulatory adaptation. Physiologically, VAC represents a dynamic balance between myocardial contractility, ventricular compliance, arterial resistance, and elasticity, ensuring hemodynamic stability and adequate oxygen delivery in utero. During the transition from fetal to neonatal circulation, the closure of placental circulation and the opening of pulmonary circulation induce profound hemodynamic changes, leading to remodeling of VAC with important implications for long-term cardiovascular health. Recent advances in echocardiography and Doppler techniques have enabled comprehensive evaluation of fetal VAC by integrating cardiac functional indices with hemodynamic parameters, facilitating early detection of abnormalities and potential risks. Emerging modalities, including speckle-tracking echocardiography, three-dimensional imaging, and artificial intelligence-assisted analysis, are expected to allow more precise and reproducible quantification of fetal VAC, thereby supporting risk stratification, optimized surveillance, and individualized prenatal management. Thus, research on fetal VAC not only deepens our understanding of cardiovascular developmental and adaptive mechanisms but also provides a clinically relevant framework for ultrasound-based assessment and decision-making in fetal medicine.}
}