@article{Shen2026, 
author = {Yong Shen and Nanjin Ding and Meijia Zheng and Tianyuan Guo and Xiaoxia Gu and Yu Liang and Chunmei Chen and Qin Li and Yonghui Zhang and Hucheng Zhu},
title = {Kaurepenoid A, a 2-nor-ent-kaurane diterpenoid with P-glycoprotein-mediated reversal of multidrug resistance activity from the fungus Bipolaris sp.},
year = {2026},
journal = {Chinese Journal of Natural Medicines},
volume = {24},
number = {10},
pages = {1251-1261},
keywords = {Bipolaris sp., Ent-kaurane, Derivatization, Multidrug resistance, P-glycoprotein},
url = {https://www.sciopen.com/article/10.1016/S1875-5364(26)61218-6},
doi = {10.1016/S1875-5364(26)61218-6},
abstract = {Chemical research on the fungus Bipolaris sp. led to the identification of seven ent-kaurane diterpenoids, kaurepenoids A–G (1–7), marking the first isolation of such diterpenoids from this genus. Kaurepenoids A–F (1–6) represent the first 2-nor-ent-kaurane diterpenoids with a fused 5/6/6/5 tetracyclic ring system. Kaurepenoid G (7) bears a rare 2,3-epoxy-ent-kaurane skeleton. Their structures and absolute configurations were elucidated by NMR, ECD calculations, and single-crystal X-ray diffraction analyses. Putative biosynthetic pathways for kaurepenoids A–F were proposed. Furthermore, the derivatization of both kaurepenoids B and C as starting materials afforded five derivatives (8–12). Among these compounds, kaurepenoid A could increase the efficacy of anticancer drug paclitaxel (PTX) by 204-fold at 20 μmol·L−1. Mechanistic investigation demonstrated that kaurepenoid A could inhibit the transport function of P-glycoprotein (P-gp) rather than affecting its expression, and the possible recognition mechanism was predicted by molecular docking.}
}