@article{Wei2026, 
author = {Xia Wei and Lishuang Guo and Xuewei Duan and Zekun Zhang and Linkun An and Juncheng Su and Cuixian Zhang},
title = {Aspergillines E−L with TDPs inhibitory and combined anti-tumor activities from marine fungus Aspergillus sp. EGF 15-0-3 as environmental-induced products},
year = {2026},
journal = {Chinese Journal of Natural Medicines},
volume = {24},
number = {8},
pages = {1015-1024},
keywords = {Environmental-induced products, TDPs inhibitory activities, Combined anti-tumor activities, Marine fungus, Aspergillus sp. EGF 15-0-3},
url = {https://www.sciopen.com/article/10.1016/S1875-5364(26)61199-5},
doi = {10.1016/S1875-5364(26)61199-5},
abstract = {Systematical screening of the metabolic profile of marine fungus Aspergillus sp. EGF 15-0-3 using OSMAC-GNPS molecular networking cascade followed by target isolation of the environmental-induced products resulted the identification of eight unprecedented indole diketopiperazine-based hybrids (1−8) featuring three distinct chemical backbones. The structures of the obtained compounds were established by combination of extensive spectroscopic analyses, X-ray crystallography, and ECD calculations. All these environmental-induced metabolites were demonstrated to be unusual tyrosyl-DNA phosphodiesterase 2 inhibitors. Compound 3, as the most outstanding example, showed selective synergistic antitumor effect when combined with the chemotherapeutic drugs.}
}