TY  - JOUR
AU  - Wei, Xia
AU  - Guo, Lishuang
AU  - Duan, Xuewei
AU  - Zhang, Zekun
AU  - An, Linkun
AU  - Su, Juncheng
AU  - Zhang, Cuixian
PY  - 2026
TI  - Aspergillines E−L with TDPs inhibitory and combined anti-tumor activities from marine fungus Aspergillus sp. EGF 15-0-3 as environmental-induced products
JO  - Chinese Journal of Natural Medicines
SN  - 2095-6975
SP  - 1015
EP  - 1024
VL  - 24
IS  - 8
AB  - Systematical screening of the metabolic profile of marine fungus Aspergillus sp. EGF 15-0-3 using OSMAC-GNPS molecular networking cascade followed by target isolation of the environmental-induced products resulted the identification of eight unprecedented indole diketopiperazine-based hybrids (1−8) featuring three distinct chemical backbones. The structures of the obtained compounds were established by combination of extensive spectroscopic analyses, X-ray crystallography, and ECD calculations. All these environmental-induced metabolites were demonstrated to be unusual tyrosyl-DNA phosphodiesterase 2 inhibitors. Compound 3, as the most outstanding example, showed selective synergistic antitumor effect when combined with the chemotherapeutic drugs.
UR  - https://doi.org/10.1016/S1875-5364(26)61199-5
DO  - 10.1016/S1875-5364(26)61199-5