@article{Zeng2026, 
author = {Hanxiao Zeng and Yaxing Wang and Chenmeng Huang and Rui Jiang and Yongfei Zhang and Zixue Chai and Jiangyang Chi and Yonghui Zhang and Zhengxi Hu},
title = {Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05},
year = {2026},
journal = {Chinese Journal of Natural Medicines},
volume = {24},
number = {9},
pages = {1110-1122},
keywords = {Talaromyces sp., α-Pyrone dimers, GNPS molecular networking, HSQC-based SMART and DeepSAT, Cardioprotective activity},
url = {https://www.sciopen.com/article/10.1016/S1875-5364(26)61207-1},
doi = {10.1016/S1875-5364(26)61207-1},
abstract = {Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A−I (1−9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represented two unprecedented classes of rearranged α-pyrone dimers, and compounds 5−7 were the first talarolactone-type dimers obtained as racemates. Extensive spectroscopic analysis, quantum chemical calculations, and X-ray diffraction analysis were used to determine their structures, including each enantiomer of racemic compounds 5−8 after chiral HPLC resolution. In human cardiomyocytes (AC16), compounds 1−6 and 8−9 attenuated injury caused by 24 h cold ischemia (CI) at 40 µmol·L−1. Moreover, compound 2 could improve CI-induced disruption of redox homeostasis via activation of the PI3K/AKT signaling pathway, representing the first fungal polyketide with such cardioprotective activity.}
}