@article{Lu2026, 
author = {Zhongyu Lu and Xiao Zhu and Xin Zhou and Xiaobin Li and Xiao Han and Guoqiang Li},
title = {Clavukellines A–N: dolabellane diterpenes from the soft coral Clavularia koellikeri},
year = {2026},
journal = {Chinese Journal of Natural Medicines},
volume = {24},
number = {9},
pages = {1123-1128},
keywords = {Clavularia koellikeri, Dolabellane diterpenes, Absolute configurations, Anti-inflammatory activity, Antithrombotic activity},
url = {https://www.sciopen.com/article/10.1016/S1875-5364(26)61209-5},
doi = {10.1016/S1875-5364(26)61209-5},
abstract = {Chemical investigation of the soft coral Clavularia koellikeri led to the isolation of fourteen new diterpenoid derivatives clavukellines A–N (1–14) featuring the dolabellane-type skeleton. Structural characterization of these compounds was accomplished through an integrated analytical strategy combining NMR spectroscopy and HR-ESI-MS. Absolute configurations were unambiguously assigned using ECD spectral simulation and DP4 + probability analysis. Preliminary pharmacological evaluation indicated that compounds 8 and 13 exhibited anti-inflammatory activity, while compounds 1–14 showed antithrombotic activity. This study reveals promising anti-inflammatory and antithrombotic potentials that warrant further investigation.}
}