TY  - JOUR
AU  - Pan, Li
AU  - Xie, Lizheng
AU  - Yang, Wenpei
AU  - Feng, Shi
AU  - Mao, Wenbao
AU  - Ye, Lei
AU  - Cheng, Hongwei
AU  - Wu, Xiao
AU  - Mao, Xiang
PY  - 2025
TI  - The role of brain–liver–gut Axis in neurological disorders
JO  - Burns & Trauma
SN  - 2321-3868
SP  - tkaf011
VL  - 13
IS  - 5
AB  - In recent years, with the increasing volume of related research, it has become apparent that the liver and gut play important roles in the pathogenesis of neurological disorders. Considering the interactions among the brain, liver, and gut, the brain–liver–gut axis has been proposed and gradually recognized. In this article, we summarized the complex network of interactions within the brain–liver–gut axis, encompassing the vagus nerve, barrier permeability, immunity and inflammation, the blood–brain barrier, gut microbial metabolites, the gut barrier, neurotoxic metabolites, and beta-amyloid (Aβ) metabolism. We also elaborated on the impact of the brain–liver–gut axis on various neurological disorders. Furthermore, we outline several therapies aimed at modulating the brain–liver–gut axis, including antibiotics, probiotics and prebiotics, fecal microbiota transplantation (FMT), vagus nerve stimulation (VNS), and dietary interventions. The focus is on elucidating possible mechanisms underlying neurological disorders pathogenesis and identifying effective treatments that are based on our understanding of the brain–liver–gut axis.
UR  - https://doi.org/10.1093/burnst/tkaf011
DO  - 10.1093/burnst/tkaf011