TY  - JOUR
AU  - Wang, Zitong
AU  - Zhao, Feng
AU  - Lang, Hongxin
AU  - Ren, Haiyue
AU  - Zhang, Qiqi
AU  - Huang, Xing
AU  - He, Cai
AU  - Xu, Chengcheng
AU  - Tan, Chiyu
AU  - Ma, Jiajie
AU  - Duan, Shu
AU  - Wang, Zhe
PY  - 2025
TI  - Organoids in skin wound healing
JO  - Burns & Trauma
SN  - 2321-3868
SP  - tkae077
VL  - 13
IS  - 1
AB  - Stem cells (SCs) can self-replicate and differentiate into multiple lineages. Organoids, 3D cultures derived from SCs, can replicate the spatial structure and physiological characteristics of organs in vitro. Skin organoids can effectively simulate the physiological structure and function of skin tissue, reliably restoring the natural skin ecology in various in vitro environments. Skin organoids have been employed extensively in skin development and pathology research, offering valuable insights for drug screening. Moreover, they play crucial roles in skin regeneration and tissue repair. This in-depth review explores the construction and applications of skin organoids in wound healing, with a focus on their construction process, including skin appendage integration, and significant advancements in wound-healing research.
UR  - https://doi.org/10.1093/burnst/tkae077
DO  - 10.1093/burnst/tkae077