@article{LI2025, 
author = {Yaqing LI and Gang KANG and Baohua MAI and Shenshu CHEN and Lianghong CHENG and Taifeng JIAO},
title = {Analysis of Piperazine-type New Psychoactive Substance 4F-MBZP in Seized Drugs},
year = {2025},
journal = {Forensic Science and Technology},
volume = {50},
number = {5},
pages = {469-474},
keywords = {drug, new psychoactive substance, 1-(4-fluorobenzyl)-4-methylpiperazine (4F-MBZP), liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry (LC-Q-TOF-MS/MS), nuclear magnetic resonance (NMR)},
url = {https://www.sciopen.com/article/10.16467/j.1008-3650.2024.0068},
doi = {10.16467/j.1008-3650.2024.0068},
abstract = {This paper aims to confirm the new psychoactive substance 1-(4-fluorobenzyl)-4-methylpiperazine (4F-MBZP) through a combination of multiple technologies. After ultrasonic extraction with methanol and separation by preparative liquid chromatography, the target was analyzed using a combination of gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry (LC-Q-TOF-MS/MS), Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance hydrogen spectroscopy (1H-NMR), respectively. Through GC-MS analysis, the main characteristic fragment ions of the unknown compound with a retention time of 9.78 min were m/z 208.1, 164.1, 109.1 and 99.1; By means of LC-Q-TOF-MS/MS detection, the quasi-molecular ion peak of the unknown compound was determined to be m/z 209.286 4, and the main characteristic ion fragments obtained by MS2 were m/z 189.183 0, 109.176 9, 99.452 0 and 83.387 1; The infrared characteristic absorption peaks of the target measured by FTIR analysis were 3517.1, 2981.5, 2943.4, 1603.9, 1517.3, 1232.0, 1168.6, 1080.2, 827.8 and 766.9 cm-1, indicating that the molecular structure of the suspicious compound contains functional groups including benzene ring, methyl, methylene, and C-N; After further analysis of proton attribution in the unknown compound structure by 1H-NMR and comparison with relevant literature that has been publicly reported, it was confirmed that the unknown compound is a new psychoactive substance called 4F-MBZP. This method is expected to be used in qualitative analysis of 4F-MBZP in seized drugs with simple operation and high accuracy, while providing reference for the detection and identification of new drugs.}
}