TY  - JOUR
AU  - LI, Yaqing
AU  - KANG, Gang
AU  - MAI, Baohua
AU  - CHEN, Shenshu
AU  - CHENG, Lianghong
AU  - JIAO, Taifeng
PY  - 2025
TI  - Analysis of Piperazine-type New Psychoactive Substance 4F-MBZP in Seized Drugs
JO  - Forensic Science and Technology
SN  - 1008-3650
SP  - 469
EP  - 474
VL  - 50
IS  - 5
AB  - This paper aims to confirm the new psychoactive substance 1-(4-fluorobenzyl)-4-methylpiperazine (4F-MBZP) through a combination of multiple technologies. After ultrasonic extraction with methanol and separation by preparative liquid chromatography, the target was analyzed using a combination of gas chromatography-mass spectrometry (GC-MS), liquid chromatography-quadrupole/time-of-flight tandem mass spectrometry (LC-Q-TOF-MS/MS), Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance hydrogen spectroscopy (1H-NMR), respectively. Through GC-MS analysis, the main characteristic fragment ions of the unknown compound with a retention time of 9.78 min were m/z 208.1, 164.1, 109.1 and 99.1; By means of LC-Q-TOF-MS/MS detection, the quasi-molecular ion peak of the unknown compound was determined to be m/z 209.286 4, and the main characteristic ion fragments obtained by MS2 were m/z 189.183 0, 109.176 9, 99.452 0 and 83.387 1; The infrared characteristic absorption peaks of the target measured by FTIR analysis were 3517.1, 2981.5, 2943.4, 1603.9, 1517.3, 1232.0, 1168.6, 1080.2, 827.8 and 766.9 cm-1, indicating that the molecular structure of the suspicious compound contains functional groups including benzene ring, methyl, methylene, and C-N; After further analysis of proton attribution in the unknown compound structure by 1H-NMR and comparison with relevant literature that has been publicly reported, it was confirmed that the unknown compound is a new psychoactive substance called 4F-MBZP. This method is expected to be used in qualitative analysis of 4F-MBZP in seized drugs with simple operation and high accuracy, while providing reference for the detection and identification of new drugs.
UR  - https://doi.org/10.16467/j.1008-3650.2024.0068
DO  - 10.16467/j.1008-3650.2024.0068