@article{Zhang2026, 
author = {Haozhi Zhang and Ningze Zhang and Ronald Man Yeung Wong and Michael Tim Yun Ong and Wenxue Tong and Ling Qin and Jiankun Xu},
title = {Turning shortcomings into advantages: The beauty of magnesium in orthopedic applications},
year = {2026},
journal = {Journal of Magnesium and Alloys},
volume = {14},
number = {C},
keywords = {Magnesium, Orthopedics, Clinical translation, Biomaterials, Regeneration medicine},
url = {https://www.sciopen.com/article/10.1016/j.jma.2025.09.038},
doi = {10.1016/j.jma.2025.09.038},
abstract = {Magnesium (Mg)-based biomaterials transform inherent limitations—rapid degradation and suboptimal strength—into therapeutic advantages for orthopedic regeneration. Contrary to industrial perceptions, the moderate corrosion rate and bone-mimetic stiffness (~30 GPa) of Mg synergistically support tissue repair: degradation products activate multiple pathways to enhance functional bone regeneration. Clinical translation milestones include China’s first NMPA-approved Mg-based 3D-printed scaffold. Future advancement hinges on three pillars: biomimetic structural design, material refinement, and smart implants. By redefining the “shortcomings” of Mg as regenerative assets, this paradigm accelerates functional bone reconstruction across orthopedic scenarios.}
}