TY  - JOUR
AU  - Zhang, Haozhi
AU  - Zhang, Ningze
AU  - Wong, Ronald Man Yeung
AU  - Ong, Michael Tim Yun
AU  - Tong, Wenxue
AU  - Qin, Ling
AU  - Xu, Jiankun
PY  - 2026
TI  - Turning shortcomings into advantages: The beauty of magnesium in orthopedic applications
JO  - Journal of Magnesium and Alloys
SN  - 2213-9567
VL  - 14
IS  - C
AB  - Magnesium (Mg)-based biomaterials transform inherent limitations—rapid degradation and suboptimal strength—into therapeutic advantages for orthopedic regeneration. Contrary to industrial perceptions, the moderate corrosion rate and bone-mimetic stiffness (~30 GPa) of Mg synergistically support tissue repair: degradation products activate multiple pathways to enhance functional bone regeneration. Clinical translation milestones include China’s first NMPA-approved Mg-based 3D-printed scaffold. Future advancement hinges on three pillars: biomimetic structural design, material refinement, and smart implants. By redefining the “shortcomings” of Mg as regenerative assets, this paradigm accelerates functional bone reconstruction across orthopedic scenarios.
UR  - https://doi.org/10.1016/j.jma.2025.09.038
DO  - 10.1016/j.jma.2025.09.038