@article{Wang2024, 
author = {Haomiao Wang and Shitao Fan and Jinxin Lin and Xuyang Zhang and Tengyuan Zhou and Ran Luo and Chao Zhang and Shuixian Zhang and Qingwu Yang and Rong Hu},
title = {Assessment of causal relationships between white matter brain imaging-derived phenotypes and CSVD-mediated Stroke: Genetic correlation and Mendelian randomization},
year = {2024},
journal = {Brain Hemorrhages},
volume = {5},
number = {6},
pages = {261-266},
keywords = {Cerebral small vessel disease, Stroke, Genetic correlation, Mendelian randomization},
url = {https://www.sciopen.com/article/10.1016/j.hest.2024.08.005},
doi = {10.1016/j.hest.2024.08.005},
abstract = {ObjectiveCerebral small vessel disease (CSVD) and its associated stroke are significant contributors to mortality and long-term disability globally. Despite this, there remains a lack of established predictors or preventive strategies for stroke mediated by CSVD, beyond the management of hypertension. In this study, we explored the potential utility of imaging-derived phenotypes (IDPs) of white matter (WM) as risk predictors for CSVD-mediated stroke and clarify the underlying causal relationships.MethodsWe performed a genetic correlation analysis to assess the relationship between WM IDPs and CSVD-mediated stroke, identifying genetically correlated pairs for follow-up Mendelian randomization (MR) studies. Subsequently, we examined the mediating role of WM IDPs in the correlation between blood pressure (BP) traits and CSVD-mediated stroke.ResultsOur findings demonstrate a significant causal relationship between genetic predisposition to increased isotropic or free water volume fraction (ISOVF) in the anterior limb of the left internal capsule (ALLIC) and CSVD-mediated stroke (IVW: odds ratio [OR] = 1.57; 95 % CI: 1.25 to 1.96, p = 8.27 × 10–5).ConclusionsThis study provides evidence for a potential causal link between WM IDPs and CSVD-mediated stroke, which may enhance the predictive capacity for CSVD-mediated stroke.}
}