TY  - JOUR
AU  - Wang, Haomiao
AU  - Fan, Shitao
AU  - Lin, Jinxin
AU  - Zhang, Xuyang
AU  - Zhou, Tengyuan
AU  - Luo, Ran
AU  - Zhang, Chao
AU  - Zhang, Shuixian
AU  - Yang, Qingwu
AU  - Hu, Rong
PY  - 2024
TI  - Assessment of causal relationships between white matter brain imaging-derived phenotypes and CSVD-mediated Stroke: Genetic correlation and Mendelian randomization
JO  - Brain Hemorrhages
SN  - 2589-238X
SP  - 261
EP  - 266
VL  - 5
IS  - 6
AB  - ObjectiveCerebral small vessel disease (CSVD) and its associated stroke are significant contributors to mortality and long-term disability globally. Despite this, there remains a lack of established predictors or preventive strategies for stroke mediated by CSVD, beyond the management of hypertension. In this study, we explored the potential utility of imaging-derived phenotypes (IDPs) of white matter (WM) as risk predictors for CSVD-mediated stroke and clarify the underlying causal relationships.MethodsWe performed a genetic correlation analysis to assess the relationship between WM IDPs and CSVD-mediated stroke, identifying genetically correlated pairs for follow-up Mendelian randomization (MR) studies. Subsequently, we examined the mediating role of WM IDPs in the correlation between blood pressure (BP) traits and CSVD-mediated stroke.ResultsOur findings demonstrate a significant causal relationship between genetic predisposition to increased isotropic or free water volume fraction (ISOVF) in the anterior limb of the left internal capsule (ALLIC) and CSVD-mediated stroke (IVW: odds ratio [OR] = 1.57; 95 % CI: 1.25 to 1.96, p = 8.27 × 10–5).ConclusionsThis study provides evidence for a potential causal link between WM IDPs and CSVD-mediated stroke, which may enhance the predictive capacity for CSVD-mediated stroke.
UR  - https://doi.org/10.1016/j.hest.2024.08.005
DO  - 10.1016/j.hest.2024.08.005