@article{Taskin2025, 
author = {Irem Culha Taskin and Yao Yao},
title = {Immune cells in intracerebral hemorrhage},
year = {2025},
journal = {Brain Hemorrhages},
volume = {6},
number = {2},
pages = {86-94},
keywords = {Intracerebral hemorrhage, Inflammatory response, Microglia, Macrophages, Neutrophils, T cells},
url = {https://www.sciopen.com/article/10.1016/j.hest.2025.02.001},
doi = {10.1016/j.hest.2025.02.001},
abstract = {Intracerebral hemorrhage (ICH), the deadliest form of stroke, is characterized by bleeding into brain parenchyma and formation of hematoma. Currently, there is no treatment available for ICH. Inflammatory response is a key pathology of ICH and plays a dual role in ICH---contributing to both secondary brain injury and recovery processes. This review discusses different types (both brain-resident and infiltrated) of immune cells and their functions during inflammation processes following ICH. Specifically, the temporal dynamics, polarization, and function of microglia/macrophages, neutrophils, lymphocytes, and astrocytes in ICH are summarized in a cell-specific manner. In addition, we also discuss key challenges and unanswered questions that need to be addressed in the future. A thorough understanding of the functions of different immune cells in ICH will provide a strong foundation for future studies and lead to the identification of novel cellular/molecular targets for therapeutic development.}
}