TY  - JOUR
AU  - Taskin, Irem Culha
AU  - Yao, Yao
PY  - 2025
TI  - Immune cells in intracerebral hemorrhage
JO  - Brain Hemorrhages
SN  - 2589-238X
SP  - 86
EP  - 94
VL  - 6
IS  - 2
AB  - Intracerebral hemorrhage (ICH), the deadliest form of stroke, is characterized by bleeding into brain parenchyma and formation of hematoma. Currently, there is no treatment available for ICH. Inflammatory response is a key pathology of ICH and plays a dual role in ICH---contributing to both secondary brain injury and recovery processes. This review discusses different types (both brain-resident and infiltrated) of immune cells and their functions during inflammation processes following ICH. Specifically, the temporal dynamics, polarization, and function of microglia/macrophages, neutrophils, lymphocytes, and astrocytes in ICH are summarized in a cell-specific manner. In addition, we also discuss key challenges and unanswered questions that need to be addressed in the future. A thorough understanding of the functions of different immune cells in ICH will provide a strong foundation for future studies and lead to the identification of novel cellular/molecular targets for therapeutic development.
UR  - https://doi.org/10.1016/j.hest.2025.02.001
DO  - 10.1016/j.hest.2025.02.001