TY  - JOUR
AU  - Xu, Jinfeng
AU  - Tian, Yuan
AU  - Zhu, Hongbin
AU  - Peng, Bing
AU  - Mo, Chunheng
PY  - 2026
TI  - Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus
JO  - Medicine Advances
SN  - 2834-4391
SP  - 115
EP  - 124
VL  - 4
IS  - 2
AB  - Gestational diabetes mellitus (GDM), which is primarily characterized by insulin resistance and impaired pancreatic β‐cell function, is one of the most prevalent adverse pregnancy outcomes. The exact pathogenesis of GDM is still unclear. Ferroptosis is a type of programmed cell death, characterized by the accumulation of iron, unrestrained lipid peroxidation, and failure of antioxidant defenses, particularly depletion of glutathione peroxidase. Interestingly, accumulating evidence suggests that ferroptosis is critically involved in the development of GDM. This review outlines the mechanisms of ferroptosis, its contribution to the pathogenesis of GDM, and emerging therapeutic interventions for GDM.
UR  - https://doi.org/10.1002/med4.70055
DO  - 10.1002/med4.70055