@article{Tang2026, 
author = {Fang Tang and Xinyu Wu and Huaxing Hong and Zhiyu Fang and Liulin Zhu and Kaiting Zhang and Yu Zhu and Jiaqian Bao and Jingyao Chen and Yiyu Chen and Haixiao Chen and Zhenghua Hong and Chao Jiang},
title = {MnB-RLG nanozyme ameliorates intervertebral disc degeneration via metabolic-redox modulation},
year = {2026},
journal = {Nano Research},
keywords = {intervertebral disc degeneration, nanozyme, mitochondrial homeostasis, mitophagy, ferroptosis, oxidative stress},
url = {https://www.sciopen.com/article/10.26599/NR.2026.94908983},
doi = {10.26599/NR.2026.94908983},
abstract = {Intervertebral disc degeneration (IDD) is a leading cause of low back pain. Oxidative stress, mitochondrial dysfunction, and lipid peroxidation-driven ferroptosis act as the core pathological drivers, forming a vicious cycle that exacerbates nucleus pulposus cell (NPC) dysfunction and extracellular matrix (ECM) degradation. Conventional therapeutic strategies are limited by single-target intervention and poor clinical efficacy, highlighting the urgent demand for multifunctional nanotherapeutics that synergistically target the complex pathological environment of IDD. Herein, we developed an interfacial electron-regulated manganese boride nanozyme conjugated with resveratrol-lipoic acid-RGD nanomicelles (MnB-RLG), which exhibited multiple enzyme-mimetic activities, including SOD-like, CAT-like and GPx-like properties. In vitro experiments revealed that MnB-RLG possessed favorable biocompatibility and efficient cellular internalization capacity, which effectively promoted proliferation and migration of NPCs. Notably, MnB-RLG markedly restrained ferroptosis and enhanced sirtuin 1 (SIRT1)/PTEN-induced kinase 1 (PINK1)/Parkin-related mitophagy markers, thereby restoring mitochondrial membrane potential and respiratory capacity, eliminating excessive ROS accumulation, and maintaining ECM homeostasis in degenerative NPCs. In a rat puncture-induced IDD model, MnB-RLG significantly alleviated disc structural collapse, maintained disc height, and preserved ECM components in vivo. Collectively, this work develops a multifunctional MnB-RLG hybrid nanozyme that exerts synergistic therapeutic effects against IDD through metabolic-redox regulation, providing a potential disease-modifying approach for the clinical management of IDD.}
}