@article{LIU2005, 
author = {Changzhen LIU and Senfang SUI},
title = {N-Terminal Truncation of TACO Inhibits PMA-Induced U937 Cell Adhesion},
year = {2005},
journal = {Tsinghua Science and Technology},
volume = {10},
number = {4},
pages = {489-495},
keywords = {cell adhesion, differentiation, TACO, U937 cell},
url = {https://www.sciopen.com/article/10.1016/S1007-0214(05)70105-X},
doi = {10.1016/S1007-0214(05)70105-X},
abstract = {The effect of TACO1-299, the N-terminal truncation of TACO, on phorbol 12-myristate 13-acetate (PMA)-induced U937 cell adhesion was investigated. Full-length TACO and several truncations were overexpressed in U937 cells. The effects of the expressed proteins on U937 cell adhesion mediated by PMA-induced differentiation were observed by fluorescence microscopy. The results show that the overexpression of TACO1-299 inhibits cell adhesion while overexpressions of the other proteins do not have this effect. The actin-binding capability of TACO1-299 was investigated and the results show that TACO1-299 lacks the ability of TACO to bind F-actin. The inhibitive effect of TACO1-299, the functional domain of TACO, suggests that TACO may play a role in cell differentiation mediating adhesion of monoblastic leukemia cells.}
}