@article{XIANG2005, 
author = {Lan XIANG and Fan LEI and Dongming XING and Wei WANG and Junhua ZHENG},
title = {Neuron Protective Constituents from Rheum Nanum and Rheum Sublanceolatum},
year = {2005},
journal = {Tsinghua Science and Technology},
volume = {10},
number = {4},
pages = {426-429},
keywords = {chemical constituents, Rheum nanum, R. sublanceolatum, neuron protective activity},
url = {https://www.sciopen.com/article/10.1016/S1007-0214(05)70094-8},
doi = {10.1016/S1007-0214(05)70094-8},
abstract = {The neuron protective activity of the chemical constituents from Rheum nanum and Rheum sublanceolatum in vitro was investigated using cultured embryonic mouse cortical cells exposed to oxygen-glucose deprivation. The protective effect was quantitatively evaluated by measuring the lactate dehydrogenase release rate. Most of the compounds reduce the lactate dehydrogenase release rate, including emodin, chrysophanol-8-O-β-D-glucopyranoside, 6-hydroxymusizin-8-O-β-D-glucopyranoside, gnetin C, torachrysone-8-O-β-D-glucopyranoside, and maesopsin, and all possess potent neuron protective activity. Chrysophanol and aloe-emodin exhibit neuron protection only at low concentrations. Emodin-8-O-β-D-glucopyranoside protects the neuron cells at high concentration. Aloe-emodin-8-O-β-D-glucopyranoside is inactive.}
}