@article{ZHANG2005, 
author = {Geng ZHANG and Yinghua CHEN},
title = {Monoclonal Antibodies Recognizing HIV-1 gp41 Could Inhibit Env-Mediated Syncytium Formation},
year = {2005},
journal = {Tsinghua Science and Technology},
volume = {10},
number = {4},
pages = {512-516},
keywords = {monoclonal antibody, cell fusion, HIV-1},
url = {https://www.sciopen.com/article/10.1016/S1007-0214(05)70109-7},
doi = {10.1016/S1007-0214(05)70109-7},
abstract = {Some monoclonal antibodies (mAbs) could inhibit infection by HIV-1. In this study, four mAbs against HIV-1 gp41 were prepared in mice. All four mAbs could bind to the recombinant soluble gp41 and recognize the native envelope glycoprotein gp160 expressed on the HIV-Env+ CHO-WT cell in flow cytometry analysis. Interestingly, the results show that all four mAbs purified by affinity chromatography could inhibit HIV-1 Env-mediated membrane fusion (syncytium formation) by 40%-60% at 10 µg/mL, which implies potential inhibitory activities against HIV-1.}
}