@article{WANG2005, 
author = {Aijun WANG and Qiang AO and Wenling CAO and Chang ZHAO and Yandao GONG and Nanming ZHAO and Xiufang ZHANG},
title = {Fiber-Based Chitosan Tubular Scaffolds for Soft Tissue Engineering: Fabrication and in Vitro Evaluation},
year = {2005},
journal = {Tsinghua Science and Technology},
volume = {10},
number = {4},
pages = {449-453},
keywords = {chitosan, tissue engineering, nerve conduit, knitting},
url = {https://www.sciopen.com/article/10.1016/S1007-0214(05)70099-7},
doi = {10.1016/S1007-0214(05)70099-7},
abstract = {Porous, two-ply tubular chitosan conduits for guided tissue regeneration were fabricated by combining the textile technique (inner layer) with the thermally induced phase separation process (outer layer). A hollow chitosan tube was prepared using an industrial warp knitting process with chitosan yarns. Then, an appropriate diameter mandrel was inserted into the pre-fabricated tube. The tube and the mandrel were dipped into the chitosan solution together, taken out, and freeze-dried. After being neutralized in alkaline solution and dried at room temperature, the mandrel was removed to create the chitosan tubular scaffold. Scanning electron micrographs show that the resulting tubes have a biphasic wall structure, with a fibrous inner layer and a semipermeable outer layer. The swelling properties and the mechanical strength before and after in vitro degradation were investigated. The biocompatibility of the scaffolds was also investigated by co-culturing neuroblastoma cells (N2A, mouse) with the scaffolds. The results suggest that these chitosan tubular scaffolds are useful for the regeneration of tissues requiring a tubular scaffold.}
}