@article{LI2026, 
author = {Yuxing LI and Xueyan MA and Ke ZHAO and Jiaxing ZHAO},
title = {Study on synthetic process of 18α-glycyrrhizic acid},
year = {2026},
journal = {Journal of China Pharmaceutical University},
volume = {57},
number = {3},
pages = {288-294},
keywords = {18α-glycyrrhizic acid, synthesis, process optimization},
url = {https://www.sciopen.com/article/10.11665/j.issn.1000-5048.2025081501},
doi = {10.11665/j.issn.1000-5048.2025081501},
abstract = {In this study, the synthetic process of 18α-glycyrrhizic acid was optimized. Using 18β-glycyrrhizic acid monoammonium salt as the starting material, the target compound 18α-glycyrrhizic acid was obtained through isomerization, esterification, and hydrolysis, with a total yield of 9.43%, purity of 99.23% and key impurity A of 0.17% (HPLC). The optimized process significantly improved the isomerization conversion rate, reduced the formation of related substances, simplified the purification steps, and enhanced both industrial scalability and cost efficiency.}
}