@article{Ning2026, 
author = {Qiang Ning and Fugong Ding and Mengjie Jia and Yuqing Zhang and Yide Liu and Wanqing Yang and Zheng Lyu and Yanping Cai and Zhanwang Zhu and Yike Liu and Bo Wei},
title = {Allelic variation at TaMYB30-B1 is associated with enhanced Fusarium head blight resistance in wheat lacking Fhb1},
year = {2026},
journal = {The Crop Journal},
volume = {14},
number = {3},
pages = {1064-1071},
keywords = {Fusarium head blight, Fhb1, Multi-omics analysis, Phenylpropanoid pathway, TaMYB30-B1},
url = {https://www.sciopen.com/article/10.1016/j.cj.2026.03.001},
doi = {10.1016/j.cj.2026.03.001},
abstract = {Fusarium head blight (FHB) threatens global wheat (Triticum aestivum L.) production and food security. Fhb1 confers stable, broad-spectrum resistance to FHB, but the underlying molecular mechanisms are not fully understood. In this study, integrated transcriptomic and proteomic analyses of near-isogenic lines for the Fhb1 locus revealed that Fhb1 coordinates a multi-layered defense network characterized by extensive transcriptome reprogramming and post-transcriptional regulation. The phenylpropanoid pathway emerged as a central downstream module, as Fhb1 coordinately upregulates the expression of genes encoding key enzymes in this pathway, including PHENYLALANINE AMMONIA LYASE (PAL), CINNAMATE 4-HYDROXYLASE (C4H), and 4-COUMARATE-CoA LIGASE (4CL). Gene regulatory network analysis identified the R2R3-MYB transcription factor TaMYB30-B1 as a key regulatory hub. A single nucleotide polymorphism (SNP) in TaMYB30-B1 was significantly associated with FHB resistance across natural wheat populations. This association was more pronounced in the absence of Fhb1. Our findings elucidate the mechanistic basis for Fhb1-mediated resistance and highlight TaMYB30-B1 as a valuable target for improving FHB resistance in wheat breeding programs.}
}