@article{Wang2026, 
author = {Changquan Wang and Yun Luo and Bin Chen and Wenzhe Chen and Jing Hong and Nan Wang and Ziyu Mao and Wenzhen Chen and Chencheng Zhang and Jiwen Xu},
title = {Clinical outcomes and resting-state brain activity alterations following centromedian thalamic nucleus deep brain stimulation in drug-resistant epilepsy},
year = {2026},
journal = {Journal of Neurorestoratology},
volume = {14},
number = {2},
keywords = {Drug-resistant epilepsy, Centromedian nucleus, Deep brain stimulation, Amplitude of low frequency fluctuations, Regional homogeneity},
url = {https://www.sciopen.com/article/10.1016/j.jnrt.2026.100278},
doi = {10.1016/j.jnrt.2026.100278},
abstract = {BackgroundTo assess the clinical efficacy of centromedian nucleus deep brain stimulation (CM-DBS) for drug-resistant epilepsy and explore its effects on neural activity using resting-state functional magnetic resonance imaging.MethodsTen patients, comprising four with Lennox–Gastaut syndrome (LGS), three with generalized epilepsy (GE) and three with multifocal epilepsy, underwent CM-DBS using thalamic segmentation for localization. Efficacy was assessed by calculating seizure frequency reduction from baseline. Two measures of resting brain activity—the amplitude of low-frequency fluctuations (ALFF), reflecting the strength of spontaneous brain signals, and regional homogeneity (ReHo), indicating the synchrony of neighboring brain regions—were analyzed to evaluate postoperative changes.ResultsMean seizure reduction across all patients was 61.8%. Six patients, comprising four with LGS and two with GE, demonstrated > 50% reduction in seizure frequency. ALFF decreased in the right putamen, left inferior temporal, left putamen, right supplementary motor area, right para-hippocampal gyrus, right thalamus, left superior frontal gyrus, left cerebellar vermis Ⅳ–Ⅴ, and right post cingulate gyrus. ReHo decreased in the left inferior temporal gyrus, left anterior cingulate gyrus, and right cerebellar lobe Ⅲ but increased in the left inferior occipital gyrus, left middle occipital gyrus, right middle occipital gyrus, left cuneus, and right calcarine.ConclusionsOur preliminary findings in a small cohort show that CM-DBS may be effective for certain drug-resistant epilepsies, such as LGS and GE. Thalamic segmentation also enhanced visualization of target structures for clinical use. ALFF/ReHo changes reflect neural reorganization and reveal key epileptic network nodes, potentially reducing CM-DBS seizure frequency.}
}