@article{Huang2026, 
author = {Zhuo Huang and Yu Zhang and Yike Li and Yang Peng and Yuping Qian and Xianbing Miao and Tao Gan and Yukun Chen and Zihan Wang and Yuguang Wang and Tianhong Dai and Ludan Zhang and Peng Jiang},
title = {A Pt-Co paired-site nanozyme with a triple-synergistic action enhances periodontitis therapy},
year = {2026},
journal = {Nano Research},
keywords = {macrophage polarization, osteogenesis, periodontitis, intermetallic nanozymes, reactive oxygen species scavenging},
url = {https://www.sciopen.com/article/10.26599/NR.2026.94908895},
doi = {10.26599/NR.2026.94908895},
abstract = {Nanozymes have emerged as promising therapeutic agents, but clinical translation remains hindered by limited catalytic efficiency, structural disorder, and single-function activity. An atomic-level ordered platinum-cobalt (Pt-Co) nanozyme was designed to overcome these limitations, achieving enhanced catalytic performance and multifunctional bioactivity. The highly uniform L10-type Pt-Co structure, featuring strong electronic coupling and lattice strain effects between Pt and Co, synergistically lowers reaction energy barriers, thereby significantly enhancing superoxide dismutase (SOD)- and catalase (CAT)-like activities for rapid scavenging of reactive oxygen species (ROS), as evidenced by 82% SOD-like inhibition (vs 46% for Pt-C catalysts) and a doubled H2O2 decomposition rate. In vitro and in vivo studies demonstrated that the nanozyme attenuated ROS-induced inflammation by shifting macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 (ROS-positive macrophages decreased from 98.1% to 29.5%), reducing inflammatory cytokine production and activating Nrf2/NF-κB signaling. Moreover, Co endowed the nanozyme with osteogenic capabilities by upregulating osteogenic gene expression, including a twofold increase in Runx2, substantially promoting bone regeneration in a mouse model of periodontitis. The dual-metal nanozyme thus serves as a versatile therapeutic platform, simultaneously addressing ROS accumulation, inflammation, and bone resorption, and offers a promising advance in the treatment of periodontitis and other oxidative stress-related diseases.}
}