@article{Vasconcelos2026, 
author = {Renata Ivo Vasconcelos and Luciana da Torre Carneiro and Raquel Ciuvalschi Maia and Thaís Hancio and Gabriela Nestal de Moraes},
title = {FOXK2 gene expression in cancer: Potential regulatory mechanisms and clinical implications},
year = {2026},
journal = {Genes & Diseases},
volume = {13},
number = {4},
keywords = {Cancer, Clinical outcomes, FOXK2 transcription factor, Gene alterations, Transcript expression},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2025.101951},
doi = {10.1016/j.gendis.2025.101951},
abstract = {FOXK2 is a transcription factor known to regulate a wide range of biological processes that are critically involved in determining cell fate. Increasing evidence shows aberrant FOXK2 expression in some tumors, with crucial biological and clinical impacts. It is important to note that the molecular mechanisms contributing to FOXK2 gene deregulation are poorly understood for most cancers. In this review, we systematically describe the FOXK2 gene expression profile across distinct tumor types and discuss its potential utility as a prognostic and diagnostic molecular marker. Notably, we explore emerging mechanisms accounting for FOXK2 deregulation, focusing on genetic and transcriptional modifications, such as gene methylation, mutation and copy number variations.}
}