@article{Dornadula2026, 
author = {Giri Rajasekhar Dornadula and Ramakrishna Chilakala and Sadak Basha Shaik and Pramod Kumar Meriga and Likhitha Chintha and Yeshwanth Gurugari and Kranthi Kumar D and Sameena Fatima Shaik and Sun Hee Cheong},
title = {Molecular mastery: Harnessing DNA technology for disease prevention},
year = {2026},
journal = {Genes & Diseases},
volume = {13},
number = {4},
keywords = {CRISPR-Cas9gene editing, Defective genes, Epigenetic alterations, RNA-based therapies, Somatic cell genome editing},
url = {https://www.sciopen.com/article/10.1016/j.gendis.2025.101976},
doi = {10.1016/j.gendis.2025.101976},
abstract = {Advances in DNA technology are revolutionizing the landscape of illness prevention, providing new opportunities to combat hereditary abnormalities and chronic diseases before they manifest. CRISPR-Cas9 gene editing, epigenetic alterations, somatic cell genome editing, and RNA-based therapies are all significant advancements in this field. These techniques enable precise changes to DNA and gene expression, potentially preventing a wide range of illnesses at their genetic origins. The following discussion delves into the transformative potential of these technologies. CRISPR-Cas9 is notable for its precision in fixing defective genes, offering promise for avoiding diseases, such as cystic fibrosis and sickle cell anemia. Epigenetic modifications caused by environmental factors are also opening up new avenues for preventing chronic illnesses and malignancies. Furthermore, somatic cell genome editing is a potential, ethically viable strategy as it targets non-reproductive cells, preventing heritable genetic alterations. Along with these developments, RNA-based therapies are emerging as a new avenue for disease prevention. This paper will explore each of these advancements, their applications, and the ethical and technical challenges involved.}
}