TY - JOUR AU - Liu, Shi AU - Han, Jiayi AU - Shi, Hongyu AU - Rui, Cheng AU - Fang, Xufeng AU - Pei, Shuang AU - Yao, Cheng AU - Wang, Xuezheng AU - Zhu, Zicheng AU - Liu, Hongyu AU - Gao, Peng AU - Luan, Feishi PY - 2026 TI - Sweet genomes provide colorful life: a review on molecularly tagged genes and biological regulation of breeding characters in watermelon and melon JO - Horticultural Plant Journal SN - 2095-9885 SP - 781 EP - 798 VL - 12 IS - 4 AB - Watermelon and melon are important members of the Cucurbitaceae family, offering high economic benefit and nutritional value. With the release and ongoing refinement of the watermelon and melon genomes, many target genes (or loci) for further biology regulation exploration and molecular breeding, have been identified. Herein, we describe recent progress in genetic mapping and molecular regulation mechanisms for fruit quality, fruit development, plant morphogenesis, and plant disease resistance. We further outline future research priorities and breeding frameworks for watermelon and melon. This review delineates molecular regulators of fruit and plant development, offering a framework to explore homologous mechanisms in other Cucurbitaceae members. UR - https://doi.org/10.1016/j.hpj.2025.12.002 DO - 10.1016/j.hpj.2025.12.002