TY  - JOUR
AU  - Wang, Jieyan
AU  - Liang, Hui
AU  - Fan, Jie
PY  - 2026
TI  - Advances in cellular and molecular mechanisms of trauma-induced organ inflammation and dysfunction
JO  - Burns & Trauma
SN  - 2321-3868
SP  - tkaf074
VL  - 14
IS  - 1
AB  - Trauma represents a significant global health issue, often resulting in devastating and long-lasting effects on the body throughout a patient's life. Organ inflammation and dysfunction caused by trauma present additional challenges for clinicians. Therefore, understanding the cellular and molecular mechanisms of post-trauma systemic inflammation and organ dysfunction is essential for improving the management of trauma. This review aims to summarize current updates on the findings that explore different mechanisms of trauma-induced inflammation and organ dysfunction, highlighting the recent understanding of the vital roles of damage-associated molecular patterns, trauma-induced cell death, organ–organ cross-talk pathways, and the gut microbiota in the development and progression of post-traumatic systemic inflammation. We also discuss new approaches that can potentially guide further investigations of trauma diagnosis, treatment, and prognosis.
UR  - https://doi.org/10.1093/burnst/tkaf074
DO  - 10.1093/burnst/tkaf074